ArticleProceedings of the National Academy of Sciences of the United States of America1996
Clustered syk tyrosine kinase domains trigger phagocytosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 135 citations in OpenAlex.
- Serum immunoglobulin and the threshold of Fc receptor-mediated immune activation.Biochimica et biophysica acta. General subjects · 2023Review
- Modular Organization of Engulfment Receptors and Proximal Signaling Networks: Avenues to Reprogram Phagocytosis.Frontiers in immunology · 2021Review
- Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis.Frontiers in cell and developmental biology · 2021Review
- A Homology Model Reveals Novel Structural Features and an Immunodominant Surface Loop/Opsonic Target in the Treponema pallidum BamA Ortholog TP_0326.Journal of bacteriology · 2015Article
- A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.BMC immunology · 2014Article
- NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts.Arthritis research & therapy · 2013Article
- Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease.Journal of neuroinflammation · 2012Article
- Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis.Archives of biochemistry and biophysics · 2011Review
- Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages.The Journal of biological chemistry · 2011Article
- Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT.The Journal of biological chemistry · 2009Article
- Modulation of microglial innate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma.Current medicinal chemistry · 2009Review
- Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.Frontiers in bioscience (Landmark edition) · 2009Review
- Mammalian septins are required for phagosome formation.Molecular biology of the cell · 2008Article
- Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation.American journal of respiratory cell and molecular biology · 2006Article
- An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.Nature immunology · 2005Article
- Rate and extent of phagocytosis in macrophages lacking vamp3.Journal of leukocyte biology · 2002Article
- Vav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosis.Molecular biology of the cell · 2002Article
- Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade.Journal of cell science · 2001Article
- Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.The Journal of experimental medicine · 2000Article
- Fc receptor-mediated phagocytosis requires CDC42 and Rac1.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phagocytosis is a phylogenetically primitive mechanism adapted by specialized cells of the immune system to ingest particulate pathogens. Recent evidence suggests that the program of specific cytoskeletal rearrangements that underlies phagocytosis may share elements with the antigen receptor signaling pathway in lymphocytes. Tyrosine phosphorylation, necessary for both lymphocyte effector function and phagocytosis, is thought to allow cytoskeletal elements to couple to the intracellular domains of antigen and Fc receptor subunits. We show here that the intracellular domains of the receptors are not inherently required for cytoskeletal coupling. Chimeric transmembrane proteins bearing syk but not src family tyrosine kinase domains are capable of autonomously triggering phagocytosis and redistribution of filamentous actin in COS cells. These responses cannot be initiated by a receptor chimera bearing a point mutation in the syk catalytic domain, and the kinase domain alone is sufficient for initiating cytoskeletal coupling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.