ArticleProceedings of the National Academy of Sciences of the United States of America1996
Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Article
- Allele-specific imbalance mapping at human orthologs of mouse susceptibility to colon cancer (Scc) loci.International journal of cancer · 2015Article
- Colitis-associated colon cancer: Is it in your genes?World journal of gastroenterology · 2015Review
- Article
- Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross.G3 (Bethesda, Md.) · 2012Article
- Identification of five novel modifier loci of Apc(Min) harbored in the BXH14 recombinant inbred strain.Carcinogenesis · 2012Article
- A two-locus system controls susceptibility to colitis-associated colon cancer in mice.Oncotarget · 2010Article
- Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.Oncogene · 2010Article
- Mouse models for the study of colon carcinogenesis.Carcinogenesis · 2009Review
- Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.PloS one · 2009Article
- Article
- A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate.Cancer science · 2003Article
- A penalized likelihood method for mapping epistatic quantitative trait Loci with one-dimensional genome searches.Genetics · 2002Article
- Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- Genetics of susceptibility to radiation-induced apoptosis in colon: two loci on chromosomes 9 and 16.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Simulation of the distribution of parental strains' genomes in RC strains of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Efficient method for rapid induction of aberrant crypt foci in rats with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Japanese journal of cancer research : Gann · 1996Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The predisposition to colon cancer is multigenetically controlled in animals and probably also in humans. We have analyzed the multigenic control of susceptibility to 1,2-dimethylhydrazine-induced colon tumors in mice by using a set of 20 homozygous CcS/Dem recombinant congenic strains, each of which contains a different random subset of approximately 12.5% of genes from the susceptible strain STS/A and 87.5% of genes from the relatively resistant strain BALB/cHeA. Some CcS/Dem strains received the alleles from the susceptible strain STS/A at one or more of the multiple colon tumor susceptibility loci and are susceptible, whereas others are resistant. Linkage analysis shows that these susceptibility genes are different from the mouse homologs of the genes known to be somatically mutated in human colon cancer (KRAS2, TP53, DCC, MCC, APC, MSH2, and probably also MLH1). Different subsets of genes control tumor numbers and size. Two colon cancer susceptibility genes, Scc1 and Scc2, map to mouse chromosome 2. The Scc1 locus has been mapped to a narrow region of 2.4 centimorgans (90% confidence interval).
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