ArticleProceedings of the National Academy of Sciences of the United States of America1996
A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 120 citations in OpenAlex.
- Aberrant mitochondrial hsp60 expression affects mitochondria homeostasis and results in muscle dystrophy and premature death.Cell death & disease · 2026Article
- Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Role of Heat Shock Proteins in Glaucoma.International journal of molecular sciences · 2019Review
- Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats.Scandinavian journal of medicine & science in sports · 2018Article
- Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis.Scientific reports · 2017Article
- Tolerization against atherosclerosis using heat shock protein 60.Cell stress & chaperones · 2016Review
- Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?Journal of diabetes research · 2016Review
- Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes.Journal of autoimmunity · 2015Article
- Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression.BioMed research international · 2015Article
- Functions of heat shock proteins in pathways of the innate and adaptive immune system.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.PloS one · 2014Article
- Intradermal injection of Hsp60 induces cytokine responses in canine atopic and healthy skin.Cell stress & chaperones · 2008Article
- Transgenic overproduction of murine 60 kDa heat shock protein in the liver does not prevent type I diabetes in NOD mice.Diabetologia · 2006Article
- Article
- Heat-shock proteins induce T-cell regulation of chronic inflammation.Nature reviews. Immunology · 2005Review
- Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Transgenic models of autoimmune disease.Clinical and experimental immunology · 2002Review
- Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases.Arthritis research · 2002Review
- Arthritis protective regulatory potential of self-heat shock protein cross-reactive T cells.Cell stress & chaperones · 2000Review
- Evidence for recognition of novel islet T cell antigens by granule-specific T cell lines from new onset type 1 diabetic patients.Clinical and experimental immunology · 2000Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
A pathogenic role for self-reactive cells against the stress protein Hsp60 has been proposed as one of the events leading to autoimmune destruction of pancreatic beta cells in the diabetes of nonobese diabetic (NOD) mice. To examine this hypothesis, we generated transgenic NOD mice carrying a murine Hsp60 transgene driven by the H-2E alpha class II promoter. This would be expected to direct expression of the transgene to antigen-presenting cells including those in the thymus and so induce immunological tolerance by deletion. Detailed analysis of Hsp60 expression revealed that the endogenous gene is itself expressed strongly in thymic medullary epithelium (and weakly in cortex) yet fails to induce tolerance. Transgenic mice with retargeted Hsp60 showed overexpression of the gene in thymic cortical epithelium and in bone marrow-derived cells. Analysis of spontaneous T-cell responses to a panel of self and heterologous Hsp60 antigens showed that tolerance to the protein had not been induced, although responses to an immunodominant 437-460 epitope implicated in disease were suppressed, probably indicating an epitope shift. This correlated with changes in disease susceptibility: insulitis in transgenic mice was substantially reduced so that pathology rarely progressed beyond periislet infiltration. This was reflected in a substantial reduction in hyperglycemia and disease. These data indicate that T cells specific for some epitopes of murine Hsp60 are likely to be involved in the islet-cell destruction that occurs in NOD mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.