ArticleProceedings of the National Academy of Sciences of the United States of America1996
Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- A resource for integrated genomic analysis of the human liver.Scientific reports · 2022Pooled it
- AI-driven designed protein epigenomics.Clinical research in oncology · 2023Article
- dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region.Cell reports · 2022Article
- New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR.Molecular oncology · 2019Article
- CRISPR/Cas9-Based Engineering of the Epigenome.Cell stem cell · 2017Review
- Molecular structures guide the engineering of chromatin.Nucleic acids research · 2017Article
- CRISPR/Cas9 in Genome Editing and Beyond.Annual review of biochemistry · 2016Review
- Promoter alteration causes transcriptional repression of the POMGNT1 gene in limb-girdle muscular dystrophy type 2O.European journal of human genetics : EJHG · 2012Article
- In vivo gene regulation using tetracycline-regulatable systems.Advanced drug delivery reviews · 2009Review
- Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L).Molecular biology reports · 2006Article
- A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors.Genome research · 2006Article
- Tumor-specific adenoviral gene therapy: transcriptional repression of gene expression by utilizing p53-signal transduction pathways.Cancer gene therapy · 2004Article
- A Krüppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene.Molecular and cellular biology · 2002Article
- Evi9 encodes a novel zinc finger protein that physically interacts with BCL6, a known human B-cell proto-oncogene product.Molecular and cellular biology · 2000Article
- Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex.Molecular and cellular biology · 2000Article
- Neuronal expression of the rat M1 muscarinic acetylcholine receptor gene is regulated by elements in the first exon.The Biochemical journal · 1999Article
- Corepressor required for adenovirus E1B 55,000-molecular-weight protein repression of basal transcription.Molecular and cellular biology · 1999Article
- Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- KRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1.The Journal of clinical investigation · 1998Article
- Adjacent proline residues in the inhibitory domain of the Oct-2 transcription factor play distinct functional roles.Nucleic acids research · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionarily conserved Krüppel-associated box (KRAB) is present in the N-terminal regions of more than one-third of all Krüppel-class zinc finger proteins. Recent experiments have demonstrated that the KRAB-A domain tethered to a promoter DNA by connecting to heterologous DNA-binding protein domain or targeted to a promoter-proximal RNA sequence acts as a transcriptional silencing of RNA polymerase II promoters. Here we show that expression of KRAB domain suppresses in vivo the activating function of various defined activating transcription factors, and we demonstrate that the KRAB domain specifically silences the activity of promoters whose initiation is dependent on the presence of a TATA box. Promoters whose accurate transcription initiation is directed by a pyrimidine-rich initiator element, however, are relatively unaffected. We also report in vitro transcription experiments indicating that the KRAB domain is able to repress both activated and basal promoter activity. Thus, the KRAB domain appears to repress the activity of certain promoters through direct communication with TATA box-dependent basal transcription machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.