ArticleJournal of molecular evolution1996
Flanking sequences of an Alu source stimulate transcription in vitro by interacting with sequence-specific transcription factors.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Identification of a minimal Alu domain required for retrotransposition.Nucleic acids research · 2025Article
- Analysis of SINE Families B2, Dip, and Ves with Special Reference to Polyadenylation Signals and Transcription Terminators.International journal of molecular sciences · 2021Article
- TFs for TEs: the transcription factor repertoire of mammalian transposable elements.Genes & development · 2021Review
- TATA-Like Boxes in RNA Polymerase III Promoters: Requirements for Nucleotide Sequences.International journal of molecular sciences · 2020Article
- Genome-wide analysis of polymerase III-transcribedGenome research · 2019Article
- A Role for the Mutagenic DNA Self-Catalyzed Depurination Mechanism in the Evolution of 7SL-Derived RNAs.Journal of molecular evolution · 2017Article
- Discovery of rare, diagnosticMobile DNA · 2017Article
- The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes.Microbiology spectrum · 2015Review
- Identification of RNA polymerase III-transcribed Alu loci by computational screening of RNA-Seq data.Nucleic acids research · 2015Article
- Orangutan Alu quiescence reveals possible source element: support for ancient backseat drivers.Mobile DNA · 2012Article
- LINEs, SINEs and other retroelements: do birds of a feather flock together?Frontiers in bioscience (Landmark edition) · 2012Review
- Origin and evolution of SINEs in eukaryotic genomes.Heredity · 2011Review
- LINEs and SINEs of primate evolution.Evolutionary anthropology · 2010Article
- The impact of retrotransposons on human genome evolution.Nature reviews. Genetics · 2009Review
- Diverse cis factors controlling Alu retrotransposition: what causes Alu elements to die?Genome research · 2009Article
- The human L1 promoter: variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity.Genome research · 2004Article
- Cis-acting influences on Alu RNA levels.Nucleic acids research · 2000Article
- K562 cells implicate increased chromatin accessibility in Alu transcriptional activation.Nucleic acids research · 2000Article
- SINE retroposons can be used in vivo as nucleation centers for de novo methylation.Molecular and cellular biology · 2000Article
- p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
An Alu source gene, called the EPL Alu, was previously isolated by a phylogenetic strategy. Sequences flanking the EPL Alu family member stimulate its RNA polymerase III (Pol III) template activity in vitro. One cis-acting element maps within a 40-nucleotide region immediately upstream to the EPL Alu. This same region contains an Ap1 site which, when mutated, abolishes the transcriptional stimulation provided by this region. The flanking sequence, as assayed by gel mobility shift, forms sequence-specific complexes with several nuclear factors including Ap1. These results demonstrate that an an ancestral Alu source sequence fortuitously acquired positive transcriptional control elements by insertion into the EPL locus, thereby providing biochemical evidence for a model which explains the selective amplification of Alu subfamilies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.