ArticleJournal of molecular evolution1996
The role and amplification of the HS Alu subfamily founder gene.
Article in Journal of molecular evolution, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Discovery of a new repeat family in the Callithrix jacchus genome.Genome research · 2016Article
- Article
- Modeling the amplification dynamics of human Alu retrotransposons.PLoS computational biology · 2005Article
- Under the genomic radar: the stealth model of Alu amplification.Genome research · 2005Article
- Active Alu element "A-tails": size does matter.Genome research · 2002Article
- Cis-acting influences on Alu RNA levels.Nucleic acids research · 2000Article
- The SRP9/14 subunit of the human signal recognition particle binds to a variety of Alu-like RNAs and with higher affinity than its mouse homolog.Nucleic acids research · 1997Article
- Flanking sequences of an Alu source stimulate transcription in vitro by interacting with sequence-specific transcription factors.Journal of molecular evolution · 1996Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A recently identified Alu element (Leeflang et al. J. Mol. Evol. 1993, 37:559-565), referred to as the "putative founder of the HS (PV) subfamily," was found to be present at orthologous loci in the human, chimpanzee, gorilla, and gibbon lineages. The evolution of this Alu suggested that it is a source gene in the evolution of Alu family repeats for one of the most recent subfamilies, HS. We have determined that this putative founder of the HS subfamily was not present at the orthologous loci in older primates, including old world and new world monkeys. Thus, this particular Alu locus has only been responsible for the establishment of a very small subfamily of Alu sequences. We have further demonstrated that this putative founder Alu was not responsible for the de novo Alu insertion into the neurofibromatosis-1 gene of an individual causing neurofibromatosis. Our data demonstrate that although the putative founder of the HS subfamily found by Leeflang et al. (1993) probably gave rise to one of the most recent subfamilies of Alu sequences, it has not been very active in retroposition.
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