ArticleJournal of clinical immunology1995
Immune deficiency following thermal trauma is associated with apoptotic cell death.
Article in Journal of clinical immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 66 citations in OpenAlex.
- Long-term sleep disturbance following burn injury: Insights from the Burn Model System.Burns : journal of the International Society for Burn Injuries · 2025Article
- Cutting edge: critical role for C5aRs in the development of septic lymphopenia in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Increased apoptosis of peripheral blood neutrophils is associated with reduced incidence of infection in trauma patients with hemorrhagic shock.The Journal of infection · 2013Article
- Effect of major burns on early and late activating markers of peripheral blood T lymphocytes.Annals of burns and fire disasters · 2012Article
- Th17 (IFNγ- IL17+) CD4+ T cells generated after burn injury may be a novel cellular mechanism for postburn immunosuppression.The Journal of trauma · 2011Article
- Is the function of alveolar macrophages altered following blunt chest trauma?Langenbeck's archives of surgery · 2011Article
- Enhanced T-cell apoptosis in human septic shock is associated with alteration of the costimulatory pathway.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
- Use of intracellular cytokine staining and bacterial superantigen to document suppression of the adaptive immune system in injured patients.Annals of surgery · 2003Article
- Mechanisms of immune resolution.Critical care medicine · 2003Review
- Caspase-3-dependent organ apoptosis early after burn injury.Annals of surgery · 1999Article
- Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin.Immunology · 1999Article
- Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand.The Journal of clinical investigation · 1997Article
- Determination of lymphocytes surface markers in patients with thermal burns and the influence of burn size on mononuclear cell subsets.Medical journal of the Islamic Republic of IranArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermal injury-associated specific immune deficiency occurs despite indicators of systemic activation of the lymphoid compartment. We investigated the possibility that postburn immune failure and T cell activation are casually related through activation-induced (apoptotic) cell death. The relationship between the cellular immune response and cell mortality was examined in cultures of peripheral blood mononuclear cells (PBMC) from 14 immunosuppressed patients with extensive burns (35-90% total body surface area). Impaired cellular immunity coincided with significantly reduced cell viability as ascertained by propidium iodide staining and dye reduction assays. Following stimulation with the mitogenic lectin, phytohemagglutinin (PHA), the majority of DNA in patient cultures was fragmented, suggesting the occurrence of apoptotic cell death. Even without stimulation a portion of patient cells was apoptotic as indicated by oligonucleosomal bands on agarose gel electrophoresis. Exogenous interleukin-2 or phorbol ester markedly reduced constitutive as well as PHA-induced DNA fragmentation. In situ demonstration of DNA strand breaks in freshly isolated patient PBMC, by a TdT-based labeling technique, confirmed that a larger fraction (up to 60%) of circulating lymphocytes was undergoing apoptosis on the periphery. These novel observations suggest that apoptosis may play a major role in thermal injury-related cellular immunodeficiency.
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