ArticleChromosoma1996
The MAN antigens are non-lamin constituents of the nuclear lamina in vertebrate cells.
Article in Chromosoma, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 66 citations in OpenAlex.
- Molecular Pathology of Laminopathies.Annual review of pathology · 2022Review
- The LEM-ESCRT toolkit: Repair and maintenance of the nucleus.Frontiers in cell and developmental biology · 2022Review
- Constitutional abnormality of nuclear membrane proteins in small cell lung carcinoma.Virchows Archiv : an international journal of pathology · 2019Article
- Article
- Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.Science signaling · 2013Article
- Generation of micronuclei during interphase by coupling between cytoplasmic membrane blebbing and nuclear budding.PloS one · 2011Article
- The nuclear envelope at a glance.Journal of cell science · 2010Article
- Emergence of micronuclei and their effects on the fate of cells under replication stress.PloS one · 2010Article
- Evaluation of mammalian cell-free systems of nuclear disassembly and assembly.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins.Biochemistry · 2006Article
- Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope.Genome biology · 2002Review
- A role for nuclear lamins in nuclear envelope assembly.The Journal of cell biology · 2001Article
- Architecture of the nuclear periphery of rat pachytene spermatocytes: distribution of nuclear envelope proteins in relation to synaptonemal complex attachment sites.Molecular biology of the cell · 1999Article
- Roles of LAP2 proteins in nuclear assembly and DNA replication: truncated LAP2beta proteins alter lamina assembly, envelope formation, nuclear size, and DNA replication efficiency in Xenopus laevis extracts.The Journal of cell biology · 1999Article
- Functional dissection of YA, an essential, developmentally regulated nuclear lamina protein in Drosophila melanogaster.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characterization of the human antiserum designated MAN has led to the identification of a subset of non-lamin proteins that are exclusively located at the nuclear periphery in all vertebrate cell types examined, from human to fish. Immunoreactive protein species were shown to comprise three major polypeptides of Mr 78000, 58000 and 40000. These antigens co-partitioned with the nuclear lamina during in situ isolation of nuclear matrices from lamin A/C-positive and -negative mammalian cells. Using double immunofluorescence, the spatial relationship of MAN antigens to type-A and type-B lamins was further examined throughout the cell cycle of lamin A/C-positive mammalian cells. In interphase HeLa and 3T3 cells, MAN antigens colocalized with both types of lamins at the periphery of the nucleus, but were absent from intranuclear foci of lamin B. As HeLa cells proceeded into mitosis, MAN antigens were seen to segregate from lamins A/C and coredistribute with lamin B. Lamins A/C disassembled during late prophase/early prometaphase and reassociated with chromatin in telophase/cytokinesis. In contrast, MAN antigens and lamin B dispersed late during prometaphase and reassembled on chromosomes in anaphase. Altogether, our data suggest that MAN antigens may play key functions in the maintenance of the structural integrity of the nuclear compartment in vertebrate cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.