ArticleHistochemistry and cell biology1995
Immunohistochemical evidence for loss of ICAM-1 by alveolar epithelial cells in pulmonary fibrosis.
Article in Histochemistry and cell biology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Whole exome sequencing of 20 patients with pulmonary hypertension caused by fibrosing mediastinitis.Chinese medical journal · 2026Article
- LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation.PLoS pathogens · 2021Article
- Potential contribution of alveolar epithelial type I cells to pulmonary fibrosis.Bioscience reports · 2017Review
- Article
- Pingyangmycin-regulated expressions of adhesion molecules in human venous malformation endothelial cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- Distribution of caveolin-1 and connexin43 in normal and injured alveolar epithelial R3/1 cells.Histochemistry and cell biology · 2005Article
- A new rat type I-like alveolar epithelial cell line R3/1: bleomycin effects on caveolin expression.Histochemistry and cell biology · 2004Article
- Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management.Transactions of the American Clinical and Climatological Association · 2004Review
- Localization of intercellular adhesion molecule-1 (ICAM-1) in the lungs of silica-exposed mice.Environmental health perspectives · 1997Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ICAM-1 is an intercellular adhesion molecule of the immunoglobulin supergene family involved in adherence of leukocytes to the endothelium and in leukocytic accumulation in pulmonary injury. In the current study, the antigen retrieval technique was used to detect ICAM-1 immunohistochemically in paraffin sections of lungs from human, mouse and rat as well as in bleomycin- or radiation-induced fibrotic lungs from rat and human. In normal lung tissue, the expression of ICAM-1 on alveolar type I epithelial cells is stronger than on alveolar macrophages and on endothelial cells. Preembedding immunoelectron microscopy of normal rat, mouse and human lung samples revealed selective ICAM-1 expression on the surface of type I alveolar epithelial cells and, to a lesser extent, on the pulmonary capillary endothelium and on alveolar macrophages. In fibrotic specimens, both focal lack and strengthening of immunostaining on the surface of type I cells was found. Alveolar macrophages were found focally lacking ICAM-1 immunoreactivity. In some cases, rat type II pneumocytes exhibited positive immunoreactions for ICAM-1. Immunoelectron microscopy with preembedded rat lungs (bleomycin-exposed cases) confirmed the altered ICAM-1 distribution at the alveolar epithelial surface. In the alveolar fluid of fibrotic rat lungs, in contrast to that from untreated controls, soluble ICAM-1 was detected by western blot analysis.
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