ArticleAnnals of the rheumatic diseases1996
Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Mechanical growth factor inhibited syndesmophyte formation and the progression of osteoarthritis and ankylosing spondylitis-like symptoms in HLA-B27/Hu-β2m transgenic rats.Arthritis research & therapy · 2025Article
- Ankylosing spondylitis: A state of the art factual backbone.World journal of radiology · 2015Review
- Polymorphisms of tumor necrosis factor-α promoter region for susceptibility to HLA-B27-positive ankylosing spondylitis in Korean population.Rheumatology international · 2011Article
- Recent studies on the genetic basis of ankylosing spondylitis.Current rheumatology reports · 2009Review
- Frequency of mutated allele CYP2D6*4 in the Turkish ankylosing spondylitis patients and healthy controls.Rheumatology international · 2009Article
- Association of the MSX2 gene polymorphisms with ankylosing spondylitis in Japanese.Journal of human genetics · 2008Article
- Genetics of ankylosing spondylitis: an update.Current rheumatology reports · 2007Review
- Non-B27 MHC associations of ankylosing spondylitis.Genes and immunity · 2007Article
- Pharmacogenetic of antirheumatic treatments: clinical implications.The pharmacogenomics journal · 2007Review
- The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.American journal of human genetics · 2004Article
- The genetic basis of spondyloarthritis.Current rheumatology reports · 2004Review
- CYP2D6 deficiency, a factor in ecstasy related deaths?British journal of clinical pharmacology · 2002Article
- Predisposing factors in the spondyloarthropathies: new insights into the role of HLA-B27.Current rheumatology reports · 2001Review
- Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.American journal of human genetics · 2001Article
- Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis.Annals of the rheumatic diseases · 2000Article
- Probing for genes in seronegative spondyloarthropathy.Current rheumatology reports · 2000Review
- CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system.British journal of clinical pharmacology · 2000Article
- Polymorphic cytochromes P450 and drugs used in psychiatry.Cellular and molecular neurobiology · 1999Review
- CYP2C19 genotype does not represent a genetic predisposition in idiopathic systemic lupus erythematosus.Annals of the rheumatic diseases · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether particular genotypes for the cytochrome P450 enzyme CYP2D6, a polymorphic enzyme, are associated with susceptibility to ankylosing spondylitis (AS) and rheumatoid arthritis (RA), or linked with any specific clinical or familial features of the two conditions.
methodsCYP2D6 genotypes were determined in 54 patients with AS, 53 patients with RA, and 662 healthy controls. Leucocyte DNA was analysed for the presence of mutations by restriction fragment length polymorphism analysis with the restriction enzyme Xbal and by two separate polymerase chain reaction assays.
resultsOn the basis of odds ratio (OR), individuals with two inactive CYP2D6 alleles were more susceptible to AS than controls (OR 2.71, 95% confidence interval (CI) 1.04 to 7.08), with a stronger effect for the CYP2D6B allele (OR 4.11, 95% CI 1.54 to 11.0). No significant differences in the distribution of overall genotypes and allele frequencies were observed between RA and controls. No significant relationships were found between the skeletal, extraskeletal or familial features of AS or RA (iritis, psoriasis, inflammatory enteropathy and rheumatoid nodules, kerato-conjunctivitis sicca, pleuritis, rheumatoid and antinuclear factors) and the overall genotype.
conclusionsOur findings suggest a modest association between homozygosity for inactive CYP2D6 alleles, particularly CYP2D6B alleles, and susceptibility to AS. However, our results fail to demonstrate a genetic link between CYP2D6 genotype and RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.