ArticleAmerican journal of human genetics1996
Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 138 citations in OpenAlex.
- Genes with abnormal DNA methylation in chorionic villi of spontaneous abortions with monosomy X.Journal of assisted reproduction and genetics · 2026Article
- Comprehensive chromosome FISH assessment of sperm aneuploidy in normozoospermic males.Journal of assisted reproduction and genetics · 2022Article
- FISH and Chimps: Insights into Frequency and Distribution of Sperm Aneuploidy in Chimpanzees (International journal of molecular sciences · 2021Article
- Analysis of meiotic segregation by triple-color fish on both total and motile sperm fractions in a t(1p;18) river buffalo bull.PloS one · 2020Article
- High accuracy of quantitative fluorescence polymerase chain reaction combined with non-invasive pre-natal testing for mid-pregnancy diagnosis of common fetal aneuploidies: A single-center experience in China.Experimental and therapeutic medicine · 2019Article
- Male infertility: establishing sperm aneuploidy thresholds in the laboratory.Journal of assisted reproduction and genetics · 2019Review
- New Biological Insights on X and Y Chromosome-Bearing Spermatozoa.Frontiers in cell and developmental biology · 2019Review
- Epigenetics in Turner syndrome.Clinical epigenetics · 2018Review
- Assessment of sperm chromatin condensation and ploidy status using flow cytometry correlates to fertilization, embryo quality and pregnancy following in vitro fertilization.Journal of assisted reproduction and genetics · 2011Article
- Reduced meiotic recombination on the XY bivalent is correlated with an increased incidence of sex chromosome aneuploidy in men with non-obstructive azoospermia.Molecular human reproduction · 2008Article
- The association between male infertility and sperm disomy: evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs.Reproductive biology and endocrinology : RB&E · 2004Article
- Analysis of human spermatozoa by fluorescence in situ hybridization with preservation of the head morphology is possible by avoiding a decondensation treatment.Journal of assisted reproduction and genetics · 2002Article
- Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy.Environmental health perspectives · 2001Article
- Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.American journal of human genetics · 2001Article
- Sex chromosomal analysis of spermatozoa from infertile men using fluorescence in situ hybridization.Journal of assisted reproduction and genetics · 2000Article
- The effects of age and abnormal sperm count on the nondisjunction of spermatozoa.Journal of assisted reproduction and genetics · 2000Article
- Implications of sperm chromosome abnormalities in recurrent miscarriage.Journal of assisted reproduction and genetics · 1999Article
- Fluorescence in situ hybridization with chromosome paint probes: a novel approach to assess aneuploidy in human sperm nuclei.Journal of assisted reproduction and genetics · 1999Article
- Genetics of human sperm.Journal of assisted reproduction and genetics · 1998Article
- Sex ratio in normal and disomic sperm: evidence that the extra chromosome 21 preferentially segregates with the Y chromosome.American journal of human genetics · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While it is known that all chromosomes are susceptible to meiotic nondisjunction, it is not clear whether all chromosomes display the same frequency of nondisjunction. By use of multicolor FISH and chromosome-specific probes, the frequency of disomy in human sperm was determined for chromosomes 1, 2, 4, 9, 12, 15, 16, 18, 20, and 21, and the sex chromosomes. A minimum of 10,000 sperm nuclei were scored from each of five healthy, chromosomally normal donors for every chromosome studied, giving a total of 418,931 sperm nuclei. The mean frequencies of disomy obtained were 0.09% for chromosome 1; 0.08% for chromosome 2; 0.11% for chromosome 4; 0.14% for chromosome 9; 0.16% for chromosome 12; 0.11% for chromosomes 15, 16, and 18; 0.12% for chromosome 20; 0.29% for chromosome 21; and 0.43% for the sex chromosomes. Data for chromosomes 1, 12, 15, and 18, and the sex chromosomes have been published elsewhere. When the mean frequencies of disomy were compared, the sex chromosomes and chromosome 21 had significantly higher frequencies of disomy than that of any other autosome studied. These results corroborate the pooled data obtained from human sperm karyotypes and suggest that the sex chromosome bivalent and the chromosome 21 bivalent are more susceptible to nondisjunction during spermatogenesis. From these findings, theories proposed to explain the variable incidence of nondisjunction can be supported or discarded as improbable.
Indexed as
Identifiers
8571962PMC1914531W1549481575What OpenQuestion holds
Registered trials
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