ArticleProceedings of the National Academy of Sciences of the United States of America1996
Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 48 citations in OpenAlex.
- A comprehensive review of glycosylated bacterial natural products.Chemical Society reviews · 2015Review
- Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.BMC structural biology · 2015Article
- From nature to the laboratory and into the clinic.Bioorganic & medicinal chemistry · 2009Article
- Inspirations, discoveries, and future perspectives in total synthesis.The Journal of organic chemistry · 2009Article
- Structure and function of glycosphingolipids and sphingolipids: recollections and future trends.Biochimica et biophysica acta · 2008Review
- Role of Stat3 in regulating p53 expression and function.Molecular and cellular biology · 2005Article
- Chemical approaches to control gene expression.Gene expression · 2000Review
- Inhibition of gene expression in human cells through small molecule-RNA interactions.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Interaction of calicheamicin gamma1(I) and its related carbohydrates with DNA-protein complexes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Complex polysaccharides as PCR inhibitors in feces: Helicobacter pylori model.Journal of clinical microbiology · 1997Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The synthetic oligosaccharide moiety of the antibiotic calicheamicin and the head-to-head dimer of this oligosaccharide are known to bind to the minor groove of DNA in a sequence-selective manner preferring distinct target sequences. We tested these carbohydrates for their ability to interfere with transcription factor function. The oligosaccharides inhibit binding of transcription factors to DNA in a sequence-selective manner, probably by inducing a conformational change in DNA structure. They also interfere with transcription by polymerase II in vitro. The effective concentrations of the oligosaccharides for inhibition of transcription factor binding and for transcriptional inhibition are in the micromolar range. The dimer is a significantly more active inhibitor than is the monomer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.