ArticleProceedings of the National Academy of Sciences of the United States of America1996
Arabidopsis MBP1 gene encodes a conserved ubiquitin recognition component of the 26S proteasome.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 143 citations in OpenAlex.
- The Structural Role of RPN10 in the 26S Proteasome and an RPN2-Binding Residue on RPN13 Are Functionally Important in Arabidopsis.International journal of molecular sciences · 2024Article
- An evolutionarily distinct chaperone promotes 20S proteasome α-ring assembly in plants.Journal of cell science · 2020Article
- Proteomic analysis of affinity-purified 26S proteasomes identifies a suite of assembly chaperones inThe Journal of biological chemistry · 2019Article
- RPN10: A Case Study for Ubiquitin Binding Proteins and More.The Plant cell · 2019Article
- Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation.Frontiers in molecular biosciences · 2019Review
- Proteolysis, synaptic plasticity and memory.Neurobiology of learning and memory · 2017Review
- The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death.Cell research · 2016Review
- Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination.The Journal of biological chemistry · 2016Article
- Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis.Molecular cell · 2015Article
- Autophagic recycling plays a central role in maize nitrogen remobilization.The Plant cell · 2015Article
- Arabidopsis SAG protein containing the MDN1 domain participates in seed germination and seedling development by negatively regulating ABI3 and ABI5.Journal of experimental botany · 2014Article
- The ubiquitination machinery of the ubiquitin system.The arabidopsis book · 2014Article
- Molecular architecture and assembly of the eukaryotic proteasome.Annual review of biochemistry · 2013Review
- The RPT2 subunit of the 26S proteasome directs complex assembly, histone dynamics, and gametophyte and sporophyte development in Arabidopsis.The Plant cell · 2011Article
- The RAD23 family provides an essential connection between the 26S proteasome and ubiquitylated proteins in Arabidopsis.The Plant cell · 2010Article
- Variably modulated gating of the 26S proteasome by ATP and polyubiquitin.The Biochemical journal · 2009Article
- S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.The EMBO journal · 2009Article
- The RPN5 subunit of the 26s proteasome is essential for gametogenesis, sporophyte development, and complex assembly in Arabidopsis.The Plant cell · 2009Article
- Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation.The Journal of biological chemistry · 2005Article
- Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiubiquitin chain attachment is a key step leading to the selective degradation of abnormal polypeptides and many important regulatory proteins by the eukaryotic 26S proteasome. However, the mechanism by which the 26S complex recognizes this posttranslational modification is unknown. Using synthetic multiubiquitin chains to probe an expression library for interacting proteins, we have isolated an Arabidopsis cDNA, designated MBP1, that encodes a 41-kDa acidic protein exhibiting high affinity for chains, especially those containing four or more ubiquitins. Based on similar physical and immunological properties, multiubiquitin binding affinities, and peptide sequence, MBP1 is homologous to subunit 5a of the human 26S proteasome. Structurally related proteins also exist in yeast, Caenorhabditis, and other plant species. Given their binding properties, association with the 26S proteasome, and widespread distribution, MBP1, S5a, and related proteins likely function as essential ubiquitin recognition components of the 26S proteasome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.