ArticleProceedings of the National Academy of Sciences of the United States of America1996
An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Systems biology approach to identify biomarkers and therapeutic targets for colorectal cancer.Biochemistry and biophysics reports · 2024Article
- MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.Cancers · 2020Review
- Inhibitory effects of Arhgap6 on cervical carcinoma cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.The Journal of biological chemistry · 2011Article
- SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes.Science signaling · 2011Article
- The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells.Cellular and molecular neurobiology · 2011Article
- Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease.PloS one · 2009Article
- ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth.Molecular and cellular neurosciences · 2007Article
- Deletion of the V2 vasopressin receptor gene in two Chinese patients with nephrogenic diabetes insipidus.BMC genetics · 2006Article
- Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.PLoS biology · 2006Article
- Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells.BMC cancer · 2005Article
- The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis.Molecular and cellular biology · 2002Article
- An X chromosome gene regulates hematopoietic stem cell kinetics.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Control of Rho GTPase function by BAR-domains.Small GTPasesArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increasingly large number of proteins involved in signal transduction have been identified in recent years and shown to control different steps of cell survival, proliferation, and differentiation. Among the genes recently identified at the tip of the long arm of the human X chromosome, a novel gene, C1, encodes a protein that appears to represent a newly discovered member of the group of signaling proteins involved in regulation of the small GTP binding proteins of the ras superfamily. The protein encoded by C1, p115, is synthesized predominantly in cells of hematopoietic origin. It is characterized by two regions of similarity to motifs present in known proteins: GAP and SH3 homologous regions. Its localization in a narrow cytoplasmic region just below the plasma membrane and its inhibitory effect on stress fiber organization indicate that p115 may down regulate rho-like GTPases in hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.