ArticleProceedings of the National Academy of Sciences of the United States of America1996
Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Immune-mediated changes in actinic keratosis following topical treatment with imiquimod 5% cream.Journal of translational medicine · 2007Trial
- Exploring the functions of NKG7 in CD4+ and CD8+ T cells during malaria.PLoS pathogens · 2026Article
- A Dual Role for NKG7 in T-cell Cytotoxicity and Longevity.Cancer immunology research · 2025Review
- Natural killer cell granule protein 7 contributes to CD8Research and practice in thrombosis and haemostasis · 2025Article
- NKG7 is a Stable Marker of Cytotoxicity Across Immune Contexts and Within the Tumor Microenvironment.European journal of immunology · 2025Article
- Unravelling NK cell subset dynamics and specific gene signatures post-ibrutinib therapy in chronic lymphocytic leukaemia via single-cell transcriptomics.BMC cancer · 2025Article
- Lysosomal NKG7 restrains mTORC1 activity to promote CD8Nature communications · 2025Article
- Cytotoxic CD4Frontiers in immunology · 2025Article
- IL-10 Is Critical for Regulation of Cytotoxic CD4+NKG7+ T Cells in Lung Allograft Rejection but Is Not Required for Allograft Acceptance.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- The role of CD4Frontiers in cellular and infection microbiology · 2024Review
- NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy.Cancer immunology research · 2022Article
- NKG7 Enhances CD8+ T Cell Synapse Efficiency to Limit Inflammation.Frontiers in immunology · 2022Article
- Cytotoxic CD4Immunity · 2021Review
- Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression.Cell reports. Medicine · 2021Article
- Preparing Membrane Proteins for Simulation Using CHARMM-GUI.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
- Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response.Scientific reports · 2020Article
- NKG7 makes a better killer.Nature immunology · 2020Article
- The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation.Nature immunology · 2020Article
- A deep learning model to predict RNA-Seq expression of tumours from whole slide images.Nature communications · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
Cytotoxic lymphocytes are characterized by their inclusion of cytoplasmic granules that fuse with the plasma membrane following target cell recognition. We previously identified a cytotoxic granule membrane protein designated p15-TIA-1 that is immunochemically related to an RNA-recognition motif (RRM)-type RNA-binding protein designated p40-TIA-1. Although it was suggested that p15-TIA-1 might be derived from p40-T1A-1 by proteolysis, N-terminal amino acid sequencing of p15-TIA-1 immunoaffinity purified from a natural killer (NK) cell line by using monoclonal antibody (mAb) 2G9 revealed that p15-T1A-1 is identical to the deduced amino acid sequence of NKG7 and GIG-1, cDNAs isolated from NK cells and granulocyte-colony-stimulating factor-treated mononuclear cells, respectively. Epitope mapping revealed that mAb 2G9 recognizes the C terminus of p15-T1A-1 and p40-T1A-1. The deduced amino acid sequence of p15-T1A-1/NKG7/GIG-1 predicts that the protein possesses four transmembrane domains, and immuno-electron microscopy localizes the endogenous protein to the membranes of cytotoxic granules in NK cells. Given its subcellular localization, we propose to rename-this protein GMP-17, for granule membrane protein of 17 kDa. Immunofluorescence microscopy of freshly isolated NK cells confirms this granular localization. Target cell-induced NK cell degranulation results in translocation of GMP-17 from granules to the plasma membrane, suggesting a possible role for GMP-17 in regulating the effector function of lymphocytes and neutrophils.
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