ArticleMolecular & general genetics : MGG1996
The molecular nature of mutations in the mt A-1 gene of the Neurospora crassa A idiomorph and their relation to mating-type function.
Article in Molecular & general genetics : MGG, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
- Mating Systems in True Morels (Microbiology and molecular biology reviews : MMBR · 2021Review
- Sex-specific gene expression during asexual development of Neurospora crassa.Fungal genetics and biology : FG & B · 2012Article
- Sex in fungi.Annual review of genetics · 2011Review
- Article
- Article
- Functional characterization of MAT1-1-specific mating-type genes in the homothallic ascomycete Sordaria macrospora provides new insights into essential and nonessential sexual regulators.Eukaryotic cell · 2010Article
- Article
- Molecular and functional analyses of poi-2, a novel gene highly expressed in sexual and perithecial tissues of Neurospora crassa.Eukaryotic cell · 2005Article
- Multiple functions of mfa-1, a putative pheromone precursor gene of Neurospora crassa.Eukaryotic cell · 2002Article
- Molecular genetics of heterokaryon incompatibility in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 2000Review
- Mutational analysis of the [Het-s] prion analog of Podospora anserina. A short N-terminal peptide allows prion propagation.Genetics · 1999Article
- Molecular characterization of tol, a mediator of mating-type-associated vegetative incompatibility in Neurospora crassa.Genetics · 1999Article
- Cell differentiation during sexual development of the fungus Sordaria macrospora requires ATP citrate lyase activity.Molecular and cellular biology · 1999Article
- Article
- Characterization of mat A-2, mat A-3 and deltamatA mating-type mutants of Neurospora crassa.Genetics · 1998Article
- Mating types and sexual development in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 1997Review
- Mating-type genes from the homothallic fungus Sordaria macrospora are functionally expressed in a heterothallic ascomycete.Genetics · 1997Article
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5 authors.
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Abstract
The 293-amino acid mt A-1 ORF of the A mating-type idiomorph of Neurospora crassa is multifunctional. It confers A mating identity and is responsible for heterokaryon incompatibility. The goal of this study was to dissect the functional regions of mt A-1. New mutants of mt A-1 selected for loss of the incompatibility function were obtained. One new mutant, A(m)99, was partially fertile as a maternal parent. This is the first time that fertility and incompatibility functions have been separated for the A idiomorph. In this mutant, the mt A-1 ORF is truncated after the first 85 amino acids, indicating that this N-terminal region is minimally sufficient for female fertility. A series of deletion constructs and frameshift alleles of mt A-1 was obtained and tested for male-mating activity and vegetative incompatibility in transformation experiments. These experiments showed that a region from position 1 to 111 is sufficient to confer incompatibility, while amino acids from position 1 to 227 are required for mating activity. A transcriptional analysis of mt A-1 showed that the mRNA is expressed both before and after fertilization. This, together with the phenotype of the A(m)99 mutant, suggests a post-fertilization function for mt A-1.
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