ArticleJournal of muscle research and cell motility1995
Essential light chain of Drosophila nonmuscle myosin II.
Article in Journal of muscle research and cell motility, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.Cellular and molecular life sciences : CMLS · 2024Article
- Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells.Nature communications · 2017Article
- Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.Annual review of cell and developmental biology · 2017Review
- The actomyosin machinery is required for Drosophila retinal lumen formation.PLoS genetics · 2014Article
- Establishment and maintenance of compartmental boundaries: role of contractile actomyosin barriers.Cellular and molecular life sciences : CMLS · 2011Review
- Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis.Developmental biology · 2010Article
- Actomyosin purse strings: renewable resources that make morphogenesis robust and resilient.HFSP journal · 2008Article
- The haplolethal region at the 16F gene cluster of Drosophila melanogaster: structure and function.Genetics · 1999Article
- Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis.Genetics · 1998Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We have cloned and sequenced a cDNA encoding the essential (alkaline) light chain of nonmuscle myosin from Drosophila melanogaster. The protein predicted from the cDNA matches partial amino acid sequence derived from essential light chain protein that copurifies with native nonmuscle myosin heavy chain. This completes the sequence of the three myosin subunits, two of which have been shown genetically to be required for morphogenesis and cytokinesis (the heavy chain encoded by zipper and the regulatory light chain encoded by spaghetti squash). The essential light chain protein is 147 amino acids in length and is 53% identical to human smooth muscle essential light chain. The sequence is consistent with the presence of four helix-loop-helix domains seen in crystallographic structures of the striated muscle myosin light chains and their close relative, calmodulin. We identified the most conserved residues among essential light chain sequences from multiple phyla and present their locations on the crystallographic structure of striated muscle essential light chain. This highlights several conserved contacts among the myosin subunits that may be important for the structure and regulation of the myosin motor. The gene encoding Drosophila nonmuscle essential light chain (Mlc-c) localizes to cytological position 5A6 and we discuss prospects for genetic analysis in this region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.