ArticleThe Journal of cell biology1996
BED1, a gene encoding a galactosyltransferase homologue, is required for polarized growth and efficient bud emergence in Saccharomyces cerevisiae.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae.Aging cell · 2013Article
- Impaired manganese metabolism causes mitotic misregulation.The Journal of biological chemistry · 2012Article
- Morphogenesis and the cell cycle.Genetics · 2012Review
- The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion.Molecular biology of the cell · 2008Article
- The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.Molecular biology of the cell · 2008Article
- Mitogen-activated protein kinase stimulation of Ca(2+) signaling is required for survival of endoplasmic reticulum stress in yeast.Molecular biology of the cell · 2003Article
- A monitor for bud emergence in the yeast morphogenesis checkpoint.Molecular biology of the cell · 2003Article
- Dynamic positioning of mitotic spindles in yeast: role of microtubule motors and cortical determinants.Molecular biology of the cell · 2000Article
- Sbe2p and sbe22p, two homologous Golgi proteins involved in yeast cell wall formation.Molecular biology of the cell · 2000Article
- MCD4 encodes a conserved endoplasmic reticulum membrane protein essential for glycosylphosphatidylinositol anchor synthesis in yeast.Molecular biology of the cell · 1999Article
- Clb5-associated kinase activity is required early in the spindle pathway for correct preanaphase nuclear positioning in Saccharomyces cerevisiae.The Journal of cell biology · 1998Article
- A morphogenesis checkpoint monitors the actin cytoskeleton in yeast.The Journal of cell biology · 1998Article
- Depolarization of the actin cytoskeleton is a specific phenotype in Saccharomyces cerevisiae.Journal of cell science · 1998Article
- Spatial regulation of exocytosis: lessons from yeast.The Journal of cell biology · 1998Review
- Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity.The EMBO journal · 1998Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
The ellipsoidal shape of the yeast Saccharomyces cerevisiae is the result of successive isotropic/apical growth switches that are regulated in a cell cycle-dependent manner. It is thought that growth polarity is governed by the remodeling of the actin cytoskeleton that is itself under the control of the cell cycle machinery. The cell cycle and the morphogenesis cycle are tightly coupled and it has been recently suggested that a morphogenesis/polarity checkpoint control monitors bud emergence in order to maintain the coupling of these two events (Lew, D. J., and S. I. Reed. 1995. J. Cell Biol. 129:739-749). During a screen based on the inability of cells impaired in the budding process to survive when the morphogenesis checkpoint control is abolished, we identified and characterized BED1, a new gene that is required for efficient budding. Cells carrying a disrupted allele of BED1 no longer have the wild-type ellipsoidal shape characteristic of S. cerevisiae, are larger than wild-type cells, are deficient in bud emergence, and depend upon an intact morphogenesis checkpoint control to survive. These cells show defects in polarized growth despite the fact that the actin cytoskeleton appears normal. Our results suggest that Bed1 is a type II membrane protein localized in the endoplasmic reticulum. BED1 is significantly homologous to gma12+, a S. pombe gene coding for an alpha-1,2,-galactosyltransferase, suggesting that glycosylation of specific proteins or lipids could be important for signaling in the switch to polarized growth and in bud emergence.
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