ArticleJapanese journal of cancer research : Gann1995
Epithelial-cadherin gene is not mutated in ductal carcinomas of the breast.
Article in Japanese journal of cancer research : Gann, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 28 citations in OpenAlex.
- Aberrant E-cadherin staining patterns in invasive mammary carcinoma.World journal of surgical oncology · 2005Article
- Low frequency of E-cadherin alterations in familial breast cancer.Breast cancer research : BCR · 2001Article
- Infrequent mutation of the H-cadherin gene on chromosome 16q24 in human breast cancers.Japanese journal of cancer research : Gann · 1997Article
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7 authors at 1 institution in 1 country.
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Abstract
We investigated mutations of the epithelial (E)-cadherin gene and loss of heterozygosity (LOH) at flanking loci using three microsatellite markers on the long arm of chromosome 16 in 25 ductal carcinomas of the breast. Expression of E-cadherin was also investigated immunohistochemically. No mutations were detected in exons 6 through 9 of the E-cadherin gene. LOH was observed more frequently (42%) at D16S402 (16q-ter) than at D16S421 (16q22.3-q23.1) (17%), which is located near the E-cadherin gene. Expression of E-cadherin was observed at the cell borders in 92% (11/12) of the tumors examined. The absence of mutations in the E-cadherin gene and its conserved expression suggest that inactivation of E-cadherin does not contribute significantly to the invasion or metastatic potential of ductal carcinomas of the breast. Furthermore, the high frequency of LOH at 16q-ter suggests the existence of another tumor suppressor gene which may play a crucial role in the genesis of ductal carcinomas of the breast.
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