ArticleImmunology1995
T-cell lung granulomas induced by sepharose-coupled Mycobacterium tuberculosis protein antigens: immunosuppressive phenomena reversed with cyclophosphamide and indomethacin.
Article in Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- The Manipulation of the Lipid Mediator Metabolism as Adjunct Host-Directed Therapy in Tuberculosis.Frontiers in immunology · 2021Review
- Platelet Activation and the Immune Response to Tuberculosis.Frontiers in immunology · 2021Review
- Repurposing Immunomodulatory Drugs to Combat Tuberculosis.Frontiers in immunology · 2021Review
- Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review.Frontiers in immunology · 2017Review
- Elastase-coupled beads as a tool for characterizing localized alveolar tissue destruction associated with the onset of emphysema.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Down-regulation of interleukin-8 secretion from Mycobacterium tuberculosis-infected monocytes by interleukin-4 and -10 but not by interleukin-13.Infection and immunity · 2001Article
- Suppressive effects of anti-inflammatory agents on human endothelial cell activation and induction of heat shock proteins.Molecular medicine (Cambridge, Mass.) · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We induced lung granulomas in BALB/c mice by intratracheal instillation of Sepharose beads coated with a Mycobacterium tuberculosis protein extract. Granulomas composed of macrophages and lymphocytes were induced. The granulomatous reaction reached its peak 3-7 days after challenge and lasted for approximately 1 month. Immunolabelling of tissue sections and bronchial washings revealed that granulomas were predominantly composed of T lymphocytes with the cytotoxic-suppressor phenotype (CD8+). Granulomas were associated with a significant decrease in anti-mycobacterial immunity manifested by a drop in delayed-type hypersensitivity reactions and antibody titres. The immunosuppressive phenomena were abolished with cyclophosphamide or indomethacin. Control granulomas induced with methylated bovine serum albumin (BSA) were smaller and composed by similar numbers of CD4+ and CD8+ cells. BSA granulomas did not alter antibody titres but they decreased delayed-type hypersensitivity to BSA which was restored to normal with indomethacin but not with cyclophosphamide. Our findings show that mycobacterial proteins anchored to Sepharose beads are granulomatogenic and that they preferentially recruit CD8+ cells which, together with locally produced prostaglandins, down-modulate cell-mediated and humoral immunity to mycobacterial antigens.
Indexed as
Identifiers
8567013PMC1384047W2412875439What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.