ArticleGut1996
Helicobacter pylori increases proliferation of gastric epithelial cells.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 145 citations in OpenAlex.
- Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches.Experimental & molecular medicine · 2020Review
- Article
- Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer.BMC gastroenterology · 2017Article
- Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer.Clinical and translational gastroenterology · 2015Article
- Helicobacter pylori protein JHP0290 exhibits proliferative and anti-apoptotic effects in gastric epithelial cells.PloS one · 2015Article
- Characterization of sonic hedgehog inhibition in gastric carcinoma cells.Oncology letters · 2014Article
- Effects of Helicobacter pylori and Heat Shock Protein 70 on the Proliferation of Human Gastric Epithelial Cells.Gastroenterology research and practice · 2014Article
- Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays.PloS one · 2012Article
- Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori.BMC gastroenterology · 2011Article
- The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.Journal of gastroenterology · 2011Article
- Cell-cycle inhibition by Helicobacter pylori L-asparaginase.PloS one · 2010Article
- Helicobacter pylori gamma-glutamyltranspeptidase induces cell cycle arrest at the G1-S phase transition.Journal of microbiology (Seoul, Korea) · 2010Article
- The 3'-to-5' exoribonuclease (encoded by HP1248) of Helicobacter pylori regulates motility and apoptosis-inducing genes.Journal of bacteriology · 2009Article
- Disturbance of apoptosis and DNA synthesis by Helicobacter pylori infection of hepatocytes.Digestive diseases and sciences · 2008Article
- Oxygen radical induced gastric mucosal cell death: apoptosis or necrosis?Digestive diseases and sciences · 2008Article
- H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade.World journal of gastroenterology · 2006Article
- Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression.World journal of gastroenterology · 2005Article
- Gastric mucosa epithelial cell kinetics are differentiated by anatomic site and Helicobacter pylori infection.Digestive diseases and sciences · 2005Article
- Gastric mucosal proliferative and total tyrosine kinases activities increase in Helicobacter pylori-induced chronic gastritis.International journal of gastrointestinal cancer · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The direct and indirect effects of helicobacter pylori on cell kinetics of gastric epithelial cell line AGS were investigated by flow cytometric analysis of Ki-67 positive cells and by MTT assay. Flow cytometric analysis of Ki-67 positivity permits detection of cells that are in S-phase, whereas the MTT assay is a colometric measure of the number of viable cells. In the absence of added stimulants, 23.06 (4.88)% mean (SD) of AGS cells were Ki-67 positive. When cells were preincubated in the presence of H pylori, there was a significant increase in Ki-67 positivity (66.20 (7.89)%, p < 0.001). This increase was not seen in cells cultured in the presence of Campylobacter jejuni (24.63 (8.11)% or Escherichia coli (21.66 (9.78)%). Pre-incubation of AGS cells with supernatants from both H pylori and mitogen activated peripheral blood lymphocytes also increased the per cent of cells that were Ki-67 positive (72.93 (8.68) and 69.96 (12.35)%; p, 0.001) respectively. Similar results were also found in MTT assay. These data show that both H pylori directly and the immune/inflammatory response to H pylori indirectly can influence the rate of epithelial cell proliferation, suggesting this bacterium may be an initiating step in gastric carcinogenesis and an important co-carcinogenic factor in H pylori positive subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.