ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology1995
Is unrecognized anaphylaxis a cause of sudden unexpected death?
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.Forensic science, medicine, and pathology · 2018Pooled it
- Electrocardiogram Features in Non-Cardiac Diseases: From Mechanisms to Practical Aspects.Journal of multidisciplinary healthcare · 2024Review
- The Role of Mast Cells in the Induction and Maintenance of Inflammation in Selected Skin Diseases.International journal of molecular sciences · 2023Review
- Cases of allergic coronary syndrome (Kounis syndrome) : what we should know.Nagoya journal of medical science · 2022Article
- Medical and pathologic characteristics of fatal anaphylaxis: a Spanish nationwide 17-year series.Forensic science, medicine, and pathology · 2019Article
- Kounis Syndrome—not a Single-organ Arterial Disorder but a Multisystem and Multidisciplinary DiseaseBalkan medical journal · 2019Article
- Fatal anaphylaxis in the United States, 1999-2010: temporal patterns and demographic associations.The Journal of allergy and clinical immunology · 2014Article
- Accumulation of eosinophils, mast cells, and basophils in the spleen and the coronary arteries in anaphylactic deaths: is the Kounis hypersensitivity associated syndrome present?Forensic science, medicine, and pathology · 2014Article
- Allergic reactions following contrast material administration: nomenclature, classification, and mechanisms.International journal of legal medicine · 2014Review
- Sudden adult death.Forensic science, medicine, and pathology · 2009Review
- [Anaphylaxis. Clinical manifestations and diagnosis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2007Review
- Death in anaphylaxis in a man with house dust mite allergy.International journal of legal medicine · 2003Article
- Postmortem findings after fatal anaphylactic reactions.Journal of clinical pathology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSerum tryptase levels reflect mast cell activation and correlate with anaphylactic reactions. Elevated post-mortem serum tryptase levels have been found in witnessed fatal anaphylaxis.
objectiveThis study was designed to examine whether or not unwitnessed anaphylaxis may be a hitherto unrecognized cause of sudden unexplained death.
methodsMast cell tryptase was measured by immunoassay in 68 post-mortem sera remaining from a previous study which reported elevated venom-specific IgE antibodies in 22 (23%) of 94 victims of sudden unexpected death. Autopsies were performed in all cases. The cause of death was independently reported by pathologists unfamiliar with the nature of this study.
resultsSerum tryptase levels were elevated (> 10 ng/mL) in nine of 68 cases. The levels could not be predicted from the clinical circumstances surrounding death. Sera from four individuals contained both elevated tryptase and previously reported elevated venom-specific IgE.
conclusionsWe conclude that mast cell activation may accompany up to 13% of sudden unexpected deaths in adults. Measurement of both tryptase and specific IgE antibody levels in post-mortem sera from persons experiencing sudden, unexpected death may identify a small subset of cases due to clinically unrecognized fatal anaphylaxis, including those due to insect stings.
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Registered trials
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