ArticleBritish journal of pharmacology1995
Characterization of the functional muscarinic receptors in the rat urinary bladder.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 99 citations in OpenAlex.
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- Concomitant alteration in number and affinity of PInternational urology and nephrology · 2018Article
- Improvement in bladder dysfunction after bladder transplantation of amniotic fluid stem cells in diabetic rats.Scientific reports · 2018Article
- Octodon degus, a new model to study the agonist and plexus-induced response in the urinary bladder.Journal of physiology and biochemistry · 2017Article
- Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology.BMC urology · 2015Review
- Article
- Temporal morphological and functional impact of complete urinary diversion on the bladder: a model of bladder disuse in rats.The Journal of urology · 2010Article
- Nerve-released acetylcholine contracts urinary bladder smooth muscle by inducing action potentials independently of IP3-mediated calcium release.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder.British journal of pharmacology · 2009Article
- Involvement of Rho kinase and protein kinase C in carbachol-induced calcium sensitization in beta-escin skinned rat and guinea-pig bladders.British journal of pharmacology · 2006Article
- Gender comparison of muscarinic receptor expression and function in rat and human urinary bladder: differential regulation of M2 and M3 receptors?Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
- Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.British journal of pharmacology · 2003Article
- Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains.British journal of pharmacology · 2002Article
- M(3) muscarinic receptors mediate contraction of human urinary bladder.British journal of pharmacology · 2002Article
- Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle.British journal of pharmacology · 2001Article
- Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry.British journal of pharmacology · 2001Article
- Pharmacological characterization of muscarinic receptors in dog isolated ciliary and urinary bladder smooth muscle.British journal of pharmacology · 2001Article
- The role of M(2)-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro.British journal of pharmacology · 2000Article
- Influence of gender and the oestrous cycle on in vitro contractile responses of the rat urinary bladder to cholinergic stimulation.British journal of pharmacology · 2000Article
- Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. Muscarinic receptors mediating contraction of the rat urinary bladder were characterized functionally in vitro by use of atropine, 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP methiodide), 4-diphenylacetoxy-N-(2-chloroethyl)-piperidine hydrochloride (4-DAMP mustard), hexahydro-sila-diphenidol hydrochloride (HHSiD), the p-fluoro analogue of hexahydro-sila-diphenidol hydrochloride (p-F-HHSiD), methoctramine, and pirenzepine. 2. (+)-cis-Dioxolane contracted bladder strips in a concentration-dependent manner with an EC50 of 0.169 +/- 0.018 microM and an Emax of 7.84 +/- 0.67 g. 3. Concentration-effect curves to (+)-cis-dioxolane were shifted to the right in the presence of the antagonists in a concentration-dependent manner. The rank order of antagonist affinities against the (+)-cis-dioxolane response was (pA2 values in the parentheses) atropine (9.28) > or = 4-DAMP methiodide (9.04) > HHSiD (8.01) > p-F-HHSiD (7.28) = pirenzepine (7.12) > or = methoctramine (6.77, 7.25). The profile resembles that associated with the M3 receptor subtype. 4. Atropine, 4-DAMP methiodide, pirenzepine, and methoctramine had no effects on the contractile response to 120 mM KCl. However, HHSiD and p-F-HHSiD decreased the response to KCl, and 4-DAMP mustard increased it. 5. Contractile responses to electrical field stimulation (1-32 Hz, 0.05 ms pulse duration) were biphasic in nature. The tonic response was suppressed more than the phasic response by all antagonists except methoctramine. The suppression was not always concentration-dependent, and did not seem to be related to antagonism of any one receptor subtype. 6. Our findings are consistent with the minority M3 receptors mediating the contractile response to muscarinic stimulation by (+)-cis-dioxolane in the rat bladder.
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