ArticleBritish journal of pharmacology1995
Characterization of muscarinic receptors mediating contractions of circular and longitudinal muscle of human isolated colon.
Article in British journal of pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
- Spatiotemporal Remodeling of Enteric Neural Pathways Underlies Colonic Dysmotility Following Spinal Cord Injury in Rats.Journal of neurogastroenterology and motility · 2026Article
- Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium.Frontiers in pharmacology · 2025Article
- Cholinergic activation of enteric glia is a physiological mechanism that contributes to the regulation of gastrointestinal motility.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Antiinflammatory effect of phytosterols in experimental murine colitis model: prevention, induction, remission study.PloS one · 2014Article
- A review and additional post-hoc analyses of the incidence and impact of constipation observed in darifenacin clinical trials.Drug, healthcare and patient safety · 2012Article
- Changes in the muscarinic receptors on the colonic smooth muscles of rats with spinal cord injury.Annals of rehabilitation medicine · 2011Article
- Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder.British journal of pharmacology · 2006Review
- Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders.Digestive diseases and sciences · 2005Article
- Mechanisms mediating cholinergic antral circular smooth muscle contraction in rats.World journal of gastroenterology · 2004Article
- Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea-pig prostate gland.British journal of pharmacology · 2000Article
- Modulation of chloride, potassium and bicarbonate transport by muscarinic receptors in a human adenocarcinoma cell line.British journal of pharmacology · 1999Article
- Differential responsiveness to contractile agents of isolated smooth muscle cells from human colons as a function of age and inflammation.Digestive diseases and sciences · 1997Article
- Functional interactions between muscarinic M2 receptors and 5-hydroxytryptamine (5-HT)4 receptors and beta 3-adrenoceptors in isolated oesophageal muscularis mucosae of the rat.British journal of pharmacology · 1996Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of seven muscarinic receptor antagonists were used to characterize the receptors which mediate carbachol-evoked contractions of intertaenial circular and taenial longitudinal muscle in human isolated colon. The effects of these antagonists were studied upon colon contractions induced by cumulatively added carbachol which had mean EC50 values of 11.7 +/- 2.3 microM (n = 8) and 12.6 +/- 2.3 microM (n = 8) respectively upon circular and longitudinal smooth muscle. 2. All antagonists displaced concentration-response curves to carbachol to the right in a parallel manner. The maximum concentration of each antagonist added (30 nM-10 microM) did not significantly suppress the maximum response. 3. In circular muscle, the M3 muscarinic receptor antagonists, 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP), hexahydrosiladiphenidol (HHSiD) and para-fluoro-hexahydrosiladiphenidol (p-F-HHSiD) inhibited responses with pA2 values of 9.41 +/- 0.23, 7.17 +/- 0.07, 6.94 +/- 0.18 respectively. The M2 muscarinic receptor antagonist, AF-DX 116, the M2/M4 muscarinic receptor antagonist, himbacine, and the M1 muscarinic receptor antagonist, pirenzepine, yielded pA2 values of 7.36 +/- 0.43, 7.47 +/- 0.14 and 7.23 +/- 0.48 respectively. The non-selective antagonist, atropine, had a pA2 of 8.72 +/- 0.28. 4. In longitudinal muscle 4-DAMP, HHSiD, p-F-HHSiD, AF-DX 116, himbacine and pirenzepine gave pA2 values of 9.09 +/- 0.16, 7.45 +/- 0.43, 7.44 +/- 0.21, 6.44 +/- 0.1, 7.54 +/- 0.40, 6.87 +/- 0.38 respectively. Atropine yielded a pA2 value of 8.60 +/- 0.08. 5. The pharmacological profile of antagonist affinities at the muscarinic receptor population responding to muscarinic agonist-evoked contraction is similar to that widely accepted as characterizing the activation of an M3 muscarinic receptor subtype, although pA2 values of some antagonists are lower than that seen in other investigations.
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