ArticleThe Journal of physiology1995
Different spatial patterns of [Ca2+] increase caused by N- and L-type Ca2+ channel activation in frog olfactory bulb neurones.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 37 citations in OpenAlex.
- Deep two-photon brain imaging with a red-shifted fluorometric Ca2+ indicator.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Sieve element Ca2+ channels as relay stations between remote stimuli and sieve tube occlusion in Vicia faba.The Plant cell · 2009Article
- In situ background estimation in quantitative fluorescence imaging.Biophysical journal · 2006Article
- Action potential backpropagation and multiglomerular signaling in the rat vomeronasal system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation.Molecular and cellular biology · 2004Article
- Conversion of myoblasts to physiologically active neuronal phenotype.Genes & development · 2004Article
- Anisotropic diffusion in mitral cell dendrites revealed by fluorescence correlation spectroscopy.Biophysical journal · 2002Article
- Fluorescence correlation spectroscopy in small cytosolic compartments depends critically on the diffusion model used.Biophysical journal · 2000Article
- Tyrosine hydroxylase expression in primary cultures of olfactory bulb: role of L-type calcium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Action potential propagation into the presynaptic dendrites of rat mitral cells.The Journal of physiology · 1997Article
- A transient, RCK4-like K+ current in cultured Xenopus olfactory bulb neurons.Pflugers Archiv : European journal of physiology · 1996Article
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2 authors at 1 institution in 1 country.
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Abstract
1. The intracellular calcium concentration ([Ca2+]i) in cultured olfactory bulb neurones of Xenopus laevis tadpoles was imaged using the calcium indicator dyes fluo-3 and Fura Red as well as a laser scanning microscope. 2. Upon extracellular application of brief pulses of a solution with high potassium concentration (high [K+]o), an increase in [Ca2+]i occurred in all neurones observed. During the first 2 days in culture this increase was highest. At later stages (more than 2 days in culture) the increase in [Ca2+]i was non-homogeneous and highest in the dendritic processes. 3. Nifedipine (10 microM) reduced the high [K+]o-induced increase in [Ca2+]i. The reduction was greatest in somata and proximal dendrites. 4. With nifedipine in the bath, the high [K+]o-induced increase of [Ca2+]i was further reduced by the application of omega-conotoxin GVIA (1 microM). The omega-conotoxin-sensitive Ca2+ influx occurred predominantly on dendritic processes. 5. Noradrenaline (NA), as well as the alpha 2-adrenergic receptor agonist clonidine, reduced the high [K+]o-induced increase of [Ca2+]i. This reduction occurred mainly on dendritic processes. 6. Our results suggest a highly non-homogeneous spatial distribution of voltage-gated Ca2+ channels in cultured olfactory bulb neurones. L-type channels were found mainly on somata and their density seemed to decrease on the dendrites with increasing distance from the soma. In contrast, nifedipine-insensitive N-type channels were mainly observed on dendrites and were blocked by omega-conotoxin. NA, as well as clonidine, markedly blocked Ca2+ influx through dendritic N-type Ca2+ channels.
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