Evidence map›Paper›PMID 8558463›Full record

ArticleThe Journal of physiology1995

Phosphorylation of caldesmon by mitogen-activated protein kinase with no effect on Ca2+ sensitivity in rabbit smooth muscle.

G F Nixon, K Iizuka, C M Haystead, T A Haystead, A P Somlyo, A V Somlyo

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Caldesmon and the regulation of cytoskeletal functions.Advances in experimental medicine and biology · 2008
    Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

G F NixonDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA.
K Iizuka
C M Haystead
T A Haystead
A P Somlyo
A V Somlyo
University of Virginia · US

Funding

THE CONTRACTILE SYSTEM OF VASCULAR SMOOTH MUSCLEP01HL019242 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI OWENS, GARY K · 1985 to 2009
$16.9M
NHLBI NIH HHS 5PO1 HL19242
6 · The paper itself

Abstract

1. Recombinant, activated mitogen-activated protein kinase (3.3 microM; p42mapk) phosphorylated caldesmon in phasic (rabbit portal vein) and tonic (rabbit femoral artery) smooth muscle strips permeabilized with Triton X-100. 2. Phosphorylation of caldesmon by p42mapk neither induced contraction of relaxed smooth muscle nor affected the Ca2+ sensitivity of submaximally contracted permeabilized phasic or tonic smooth muscle.

Indexed as

AnimalsCalciumCalcium-Calmodulin-Dependent Protein KinasesCalmodulin-Binding ProteinsEnzyme ActivationFemoral ArteryIn Vitro TechniquesMaleMitogen-Activated Protein Kinase 1Muscle ContractionMuscle, Smooth, VascularOctoxynolPhosphorylationPortal VeinProtein-Tyrosine KinasesRabbitsCalciumCalcium-Calmodulin-Dependent Protein KinasesCalmodulin-Binding ProteinsMitogen-Activated Protein Kinase 1OctoxynolProtein-Tyrosine Kinases

Identifiers

PMID8558463
PMCPMC1156572
OpenAlexW2015697756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.