ArticleThe Histochemical journal1995
Expression of the CD15 antigen (Lewis x) in breast cancer.
Article in The Histochemical journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- SSEA-1 Correlates With the Invasive Phenotype in Breast Cancer.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers.Cell reports. Medicine · 2023Article
- Breast tumor microenvironment structures are associated with genomic features and clinical outcome.Nature genetics · 2022Article
- Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer.Cell reports. Medicine · 2022Article
- Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis.Cancer biomarkers : section A of Disease markers · 2022Article
- Cracking the Breast Cancer Glyco-Code through Glycan-Lectin Interactions: Targeting Immunosuppressive Macrophages.International journal of molecular sciences · 2021Review
- Glycosylation and its implications in breast cancer.Expert review of proteomics · 2019Review
- Fucosylated Antigens in Cancer: An Alliance toward Tumor Progression, Metastasis, and Resistance to Chemotherapy.Frontiers in oncology · 2018Review
- Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues.Endocrine pathology · 2016Article
- TNF-α enhancement of CD62E mediates adhesion of non-small cell lung cancer cells to brain endothelium via CD15 in lung-brain metastasis.Neuro-oncology · 2016Article
- Development and characterization of a specific IgG monoclonal antibody toward the Lewis x antigen using splenocytes of Schistosoma mansoni-infected mice.Glycobiology · 2013Article
- Invasive breast cancer in Argentine women: association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature.Breast cancer (Dove Medical Press) · 2011Article
- The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker.Journal of translational medicine · 2010Article
- Viruses and breast cancer.Cancers · 2010Article
- Cell surface associated alpha-L-fucose moieties modulate human breast cancer neoplastic progression.Pathology oncology research : POR · 2008Article
- Classical Hodgkin's disease. Clinical impact of the immunophenotype.The American journal of pathology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of the cell adhesion molecule CD15 (also known as Lewis x) by breast cancers and by adjacent normal and benign breast epithelium was investigated in a series of 98 tumours. Immunohistochemistry was performed on paraffin sections using the anti-CD15 monoclonal mouse IgM antibody Dako-M1. Some 35% of cancers expressed CD15, as did 45% of normal and 60% of hyperplasia. No association was observed between cancer cell staining, or any epithelial staining (cancer, benign and normal), and tumour size, histological grade, nodal status, age at diagnosis or the frequency of 'events' (recurrence or death). Chi-squared tests in each case were non-significant. The pattern of CD15 expression by breast cancer was frequently associated with the leading edge of invading tumour or with the outer edge of boli of carcinoma in situ, possibly suggesting a potential role in invasiveness, and with cancer cells trapped intravascularly, possibly suggesting a role in metastasis.
Indexed as
Identifiers
8557532W2039873834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.