ArticleInfection and immunity1996
Reconstitution of B-cell-depleted mice with B cells restores Th2-type immune responses during Plasmodium chabaudi chabaudi infection.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection.Infection and immunity · 2017Article
- Helminth parasites alter protection against Plasmodium infection.BioMed research international · 2014Review
- Antigen-presenting cell function during Plasmodium yoelii infection.Infection and immunity · 2002Article
- Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice.Clinical and experimental immunology · 1999Article
- Modulation of experimental blood stage malaria through blockade of the B7/CD28 T-cell costimulatory pathway.Immunology · 1999Article
- CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A role for B cells in the development of T cell helper function in a malaria infection in mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis.Infection and immunity · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In mice depleted of B cells from birth by treatment with anti-immunoglobulin M(mu) antibodies, progression from a Th1- to a Th2-regulated immune response during primary infection with Plasmodium chabaudi chabaudi fails to occur. While Th1-type immunity limits parasitemia, in the absence of B cells, chronic low-grade infections persist. Here, we show that reconstituting immune, and to a lesser extent naive, B cells to mice rendered deficient in B-cell function through anti-immunoglobulin M(mu) pretreatment restores the CD4+ T-cell response to the Th2 type later in P. c. chabaudi infection and with it the capacity to eliminate infection. This finding provides clear evidence that B cells are required for switching the balance of immune regulation between CD4+ T cells from Th1 to Th2 during P.c. chabaudi infection and supports the concept that B cells, through antibody production, are needed for effective antimalarial immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.