ArticleInfection and immunity1996
Vitamin A deficiency predisposes to Staphylococcus aureus infection.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 77 citations in OpenAlex.
- Vitamin A treatment for severe sepsis in humans; a prospective randomized double blind placebo-controlled clinical trial.Clinical nutrition ESPEN · 2019Trial
- Association between vitamin A status, inflammations, and infections in children 36-59 months of age in rural Burkina Faso: A cross - sectional study.Journal of health, population, and nutrition · 2025Article
- Dynamic multi-omics mechanisms underpinning retinol tolerance: stage-specific reconstruction of skin barrier function and host-microbiome metabolic interactions.Frontiers in microbiology · 2025Article
- The Effect of Retinoic Acid on Neutrophil Innate Immune Interactions With Cutaneous Bacterial Pathogens.Infectious microbes & diseases · 2024Article
- Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies.Frontiers in microbiology · 2024Review
- Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases.Pharmacological reports : PR · 2023Review
- Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis.International journal of molecular sciences · 2023Article
- Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research.Nutrients · 2022Review
- Article
- Effect of Different Combinations of Dietary Vitamin A, Protein Levels, and Monensin on Inflammatory Markers and Metabolites, Retinol-Binding Protein, and Retinoid Status in Periparturient Dairy Cows.Animals : an open access journal from MDPI · 2021Article
- Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review.Nutrients · 2021Review
- Vitamin A deficiency in critically ill children with sepsis.Critical care (London, England) · 2019Article
- Vitamin A improve Th17 and Treg regulation in systemic lupus erythematosus.Clinical rheumatology · 2016Article
- Inhibition of Methicillin-resistant Staphylococcus aureus-induced cytokines mRNA production in human bone marrow derived mesenchymal stem cells by 1,25-dihydroxyvitamin D3.BMC cell biology · 2014Article
- Retinol suppresses the activation of Toll-like receptors in MyD88- and STAT1-independent manners.Inflammation · 2013Article
- 9-cis retinoic acid inhibits inflammatory responses of adherent monocytes and increases their ability to induce classical monocyte migration.Journal of innate immunity · 2012Article
- Immunization protected well nourished mice but not undernourished ones from lung injury in Methicillin-resistant Staphylococcus aureus (MRSA) infection.BMC microbiology · 2009Article
- High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation.Gastroenterology · 2009Article
- Regulation of FoxP3 regulatory T cells and Th17 cells by retinoids.Clinical & developmental immunology · 2008Review
- Bacteraemia among severely malnourished children infected and uninfected with the human immunodeficiency virus-1 in Kampala, Uganda.BMC infectious diseases · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the consequences of vitamin A deficiency in a rat model of T-cell-dependent and superantigen-mediated Staphylococcus aureus arthritis. After intravenous inoculation of enterotoxin A-producing staphylococci, the vitamin-A-deficient rats showed a decreased weight gain compared with the paired fed controls despite equal food consumption. The control rats developed arthritis in the first few days after bacterial inoculation, with a peak frequency at day 5, and then gradually recovered; however, the frequency of arthritis 18 days after bacterial inoculation was 86% among the vitamin A-deficient rats and 44% among the control rats. During this period, 3 of 10 deficient rats and 1 of 10 control rats died. Further in vitro analysis revealed that T-cell responses to S. aureus were significantly higher in the vitamin A-deficient rats than in the control animals. In contrast, B-cell reactivity, measured as immunoglobulin levels, autoantibody levels, and specific antibacterial antibody levels in serum, did not differ between the groups. Interestingly, the innate host defense mechanisms against S. aureus were also profoundly affected by vitamin A deficiency. Thus, despite a larger number of circulating phagocytic cells in the vitamin-A-deficient group, the capacity to phagocytize and exert intracellular killing of S. aureus was significantly decreased in comparison with the control rats. Furthermore, serum from the vitamin A-deficient rats inoculated with Staphylococcus aureus displayed decreased complement lysis activity. Our results suggest that the increased susceptibility to S. aureus infection observed in the vitamin-A-deficient rats is due to a concerted action of antigen-specific T-cell hyperactivity, impaired function of the phagocytes, and decreased complement activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.