ArticleHuman genetics1996
DNA polymorphisms in adhesion molecule genes--a new risk factor for early atherosclerosis.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Pooled it
- Heterogeneous effect of two selectin gene polymorphisms on coronary artery disease risk: a meta-analysis.PloS one · 2014Pooled it
- Association of A561C and G98T polymorphisms in E-selectin gene with coronary artery disease: a meta-analysis.PloS one · 2013Pooled it
- Pathophysiological mechanisms and therapeutic potential of E-selectin in pulmonary arterial hypertension.Frontiers in immunology · 2026Review
- Soluble L-Selectin as an Independent Biomarker of Bronchial Asthma.Journal of clinical laboratory analysis · 2015Article
- Association of rs5368 and rs3917406 polymorphisms in E-selectin gene with premature coronary artery disease in Chinese Han population.International journal of clinical and experimental medicine · 2015Article
- Correlation between polymorphisms of the E-selectin gene, hepatitis B virus DNA copies, pre-S1 antigen and clinical outcomes during chronic hepatitis B.International journal of clinical and experimental medicine · 2015Article
- Genetics of coronary heart disease with reference to ApoAI-CIII-AIV gene region.World journal of cardiology · 2014Review
- Association of E-selectin gene polymorphism and serum PAPP-A with carotid atherosclerosis in end-stage renal disease.Molecular diagnosis & therapy · 2014Article
- Genetic variations in E-selectin and ICAM-1: relation to atherosclerosis.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.Journal of cardiothoracic and vascular anesthesia · 2010Article
- Soluble TWEAK plasma levels as a novel biomarker of endothelial function in patients with chronic kidney disease.Clinical journal of the American Society of Nephrology : CJASN · 2009Article
- Molecular genetics of atherosclerosis.Human genetics · 2009Review
- Synergistic effects between 561A > C and 98G > T polymorphisms of E-selectin gene and hypercholesterolemia in determining the susceptibility to coronary artery disease.Heart and vessels · 2008Article
- Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force.Nature immunology · 2006Article
- Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction.Immunogenetics · 2006Article
- No association between E- and L-selectin genes and SLE: soluble L-selectin levels do correlate with genotype and a subset in SLE.Genes and immunity · 2005Article
- Association between single-nucleotide polymorphisms in selectin genes and immunoglobulin A nephropathy.American journal of human genetics · 2002Article
- Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies.Heart (British Cardiac Society) · 2002Review
- Novel SNPs in the CD18 gene validate the association with MPO-ANCA+ vasculitis.Genes and immunity · 2001Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To contribute to the analysis of the genetic background of atherosclerosis, especially endothelial dysfunction, we searched for DNA polymorphisms in the genes encoding E-, P-, and L-selectin, and ICAM-I and VCAM-I. We detected 17 mutations by single-strand conformation polymorphisms analysis and direct sequencing. Five of them resulted in an amino acid substitution. In E-selectin, exchanges from serine to arginine (position 128), from leucine to phenylalanine (position 554), and a DNA mutation from guanine to thymine (position 98) present significantly different allele frequencies in young patients with angiographically established, severe atherosclerosis, compared with an unselected population. Results suggest that these polymorphisms are associated with a higher risk for early severe atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.