ArticleThe EMBO journal1995
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 267 citations in OpenAlex.
- PKCζ facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model.Oncogene · 2019Article
- Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.British journal of pharmacology · 2019Article
- Article
- Article
- Overexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activation.Cellular signalling · 2014Article
- TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signaling in HT-29/B6 cells.Mucosal immunology · 2014Article
- Protein kinase C-ζ mediates lung injury induced by diesel exhaust particles.American journal of respiratory cell and molecular biology · 2013Article
- Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5.PloS one · 2013Article
- Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications.Journal of biomedical science · 2012Article
- The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages.PloS one · 2011Article
- Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells.British journal of cancer · 2010Article
- Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.Cell death and differentiation · 2009Review
- Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor.Experimental & molecular medicine · 2009Article
- Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells.Hepatology (Baltimore, Md.) · 2009Article
- A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.Cancer research · 2009Article
- Protein kinase C isoforms: Multi-functional regulators of cell life and death.Frontiers in bioscience (Landmark edition) · 2009Review
- The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.Cancer research · 2008Article
- Activation of keratinocyte protein kinase C zeta in psoriasis plaques.The Journal of investigative dermatology · 2008Article
- Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer.Cancer research · 2008Article
- Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin.British journal of pharmacology · 2006Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein kinase C zeta (zeta PKC) is critically involved in the control of a number of cell functions, including proliferation and nuclear factor kappa B (NF-kappa B) activation. Previous studies indicate that zeta PKC is an important step downstream of Ras in the mitogenic cascade. The stimulation of Ras initiates a kinase cascade that culminates in the activation of MAP kinase (MAPK), which is required for cell growth. MAPK is activated by phosphorylation by another kinase named MAPK kinase (MEK), which is the substrate of a number of Ras-activated serine/threonine kinases such as c-Raf-1 and B-Raf. We show here that MAPK and MEK are activated in vivo by an active mutant of zeta PKC, and that a kinase-defective dominant negative mutant of zeta PKC dramatically impairs the activation of both MEK and MAPK by serum and tumour necrosis factor (TNF alpha). The stimulation of other kinases, such as stress-activated protein kinase (SAPK) or p70S6K, is shown here to be independent of zeta PKC. The importance of MEK/MAPK in the signalling mechanisms activated by zeta PKC was addressed by using the activation of a kappa B-dependent promoter as a biological read-out of zeta PKC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.