ArticleThe EMBO journal1995
CAT5, a new gene necessary for derepression of gluconeogenic enzymes in Saccharomyces cerevisiae.
Article in The EMBO journal, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 62 citations in OpenAlex.
- Balanced CoQMicrobial cell (Graz, Austria) · 2017Article
- Differential roles of the glycogen-binding domains of beta subunits in regulation of the Snf1 kinase complex.Eukaryotic cell · 2010Article
- NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.Aging cell · 2009Article
- The molecular basis for relative physiological functionality of the ADP/ATP carrier isoforms in Saccharomyces cerevisiae.Genetics · 2008Article
- Endogenous synthesis of coenzyme Q in eukaryotes.Mitochondrion · 2007Review
- Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis.The Journal of biological chemistry · 2006Article
- Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria.The Biochemical journal · 2006Article
- Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria.The Biochemical journal · 2004Article
- Article
- Regulatory elements in the FBP1 promoter respond differently to glucose-dependent signals in Saccharomyces cerevisiae.The Biochemical journal · 2001Article
- Patterns of metabolic activity during aging of the wild type and longevity mutants of Caenorhabditis elegans.Journal of the American Aging Association · 2000Article
- The yeast trimeric guanine nucleotide-binding protein alpha subunit, Gpa2p, controls the meiosis-specific kinase Ime2p activity in response to nutrients.Molecular and cellular biology · 1999Article
- Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes.The EMBO journal · 1998Article
- Yeast carbon catabolite repression.Microbiology and molecular biology reviews : MMBR · 1998Review
- FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences.The EMBO journal · 1998Article
- Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p.Molecular and cellular biology · 1997Article
- Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8.Nucleic acids research · 1996Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PCK1 encoding phosphoenolpyruvate carboxykinase is transcriptionally regulated by two upstream activating elements. By screening for mutants that failed to derepress a UAS2PCK1-CYC1-lacZ reporter gene we isolated the new recessive derepression mutation cat5. The CAT5 gene encodes a protein of 272 amino acids showing a 42% identity to the ZC395.2 gene product of Caenorhabditis elegans whose function is unknown. Deletion of CAT5 caused a complete loss of glucose derepression affecting gluconeogenic key enzymes. Respiration, but not mitochondrial cytochrome c oxidase activity, was also affected. CAT5 expression is 5- to 6-fold repressed by glucose, and CAT5 transcriptional activation was dependent on CAT1 (SNF1), CAT8 and CAT5 itself. The CAT5 gene is necessary for UAS1PCK1 and UAS2PCK1 protein binding since a carbon source-specific interaction was no longer detectable in cat5 mutants. Glucose derepression of gluconeogenesis depends on the active Cat1 (Snf1) protein kinase and the Cat8 zinc cluster activator. Mig1p-independent overexpression of CAT8 did not stimulate activation of gluconeogenic promoters in cat1 and in cat5 mutants. Since Cat8p multicopy expression suppresses the ethanol growth deficiency in cat1 (snf1) mutants, these results indicate that activation of Cat8p by the Cat1p (Snf1p) kinase and the Cat5p protein might be necessary for release from glucose repression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.