ArticleClinical and diagnostic laboratory immunology1994
Rotavirus-specific intestinal immune response in mice assessed by enzyme-linked immunospot assay and intestinal fragment culture.
Article in Clinical and diagnostic laboratory immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Mucosal and systemic neutralizing antibodies to norovirus induced in infant mice orally inoculated with recombinant rotaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice.Journal of pediatric gastroenterology and nutrition · 2012Article
- Rotavirus differentially infects and polyclonally stimulates human B cells depending on their differentiation state and tissue of origin.Journal of virology · 2010Article
- The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation.Journal of virology · 2004Article
- Specific mucosal IgA immunity in turkey poults infected with turkey coronavirus.Veterinary immunology and immunopathology · 2002Article
- Growth of rotaviruses in primary pancreatic cells.Journal of virology · 2002Article
- Effect of water-based microencapsulation on protection against EDIM rotavirus challenge in mice.Journal of virology · 1998Article
- Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus.Journal of virology · 1998Article
- Relative importance of rotavirus-specific effector and memory B cells in protection against challenge.Journal of virology · 1998Article
- Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice.Journal of virology · 1997Article
- Systematic and intestinal antibody-secreting cell responses and correlates of protective immunity to human rotavirus in a gnotobiotic pig model of disease.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Primate rotavirus strain RRV and bovine strain WC3 or reassortants made between these animal viruses and human rotaviruses have been administered to infants as candidate vaccines. We compared RRV and WC3 in a murine model of oral infection. We determined the relative capacities of these viruses to induce a virus-specific humoral immune response by intestinal lymphocytes as tested by enzyme-linked immunospot assay, intestinal fragment culture, and enzyme-linked immunosorbent assay of intestinal contents. We found that inoculation of mice with RRV induced higher frequencies of virus-specific immunoglobulin A (IgA)-secreting cells in the lamina propria, greater quantities of virus-specific IgA in intestinal fragment cultures, and greater quantities of virus-specific IgA in intestinal secretions than did inoculation with WC3 or inactivated RRV (iRRV). The induction of an IgA response in serum was predictive of an IgA response among intestinal lymphocytes after inoculation with RRV but not WC3. In addition, large quantities of IgG, IgA, and IgM not specific for rotavirus were produced in fragment cultures from mice inoculated with RRV but not in cultures from mice inoculated with WC3 or iRRV. Possible mechanisms of RRV-induced polyclonal stimulation of intestinal B cells are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.