ArticleAmerican journal of human genetics1996
Familial recurrence-pattern analysis of nonsyndromic isolated cleft palate--a Danish Registry study.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic development.International journal of oral science · 2026Article
- Association of Single-Nucleotide Polymorphisms ofIndian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2022Article
- Article
- Craniofacial disorders associated with airway obstruction in the neonate.Seminars in fetal & neonatal medicine · 2016Review
- Developments in our understanding of the genetic basis of birth defects.Birth defects research. Part A, Clinical and molecular teratology · 2015Review
- Obstructive sleep apnoea in children with craniofacial syndromes.Paediatric respiratory reviews · 2015Review
- Are epidemiological approaches suitable to study risk/preventive factors for human birth defects?Current epidemiology reports · 2015Article
- Clinical and Radiographic Assessment of Secondary Bone Graft Outcomes in Cleft Lip and Palate Patients.International scholarly research notices · 2014Article
- Genetic significance of muscle segment homeo box1 gene in South Indian population for cleft lip and palate.Indian journal of human genetics · 2012Article
- Palatal and oral manifestations of Muenke syndrome (FGFR3-related craniosynostosis).The Journal of craniofacial surgery · 2012Review
- The evolution of human genetic studies of cleft lip and cleft palate.Annual review of genomics and human genetics · 2012Review
- Genetics and management of the patient with orofacial cleft.Plastic surgery international · 2012Article
- Risk of oral clefts in twins.Epidemiology (Cambridge, Mass.) · 2011Article
- Cleft lip and palate: understanding genetic and environmental influences.Nature reviews. Genetics · 2011Review
- Recurrence risk for offspring of twins discordant for oral cleft: a population-based cohort study of the Danish 1936-2004 cleft twin cohort.American journal of medical genetics. Part A · 2010Article
- A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance.Journal of medical genetics · 2010Article
- Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms.Human genetics · 2009Article
- Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development.Experimental & molecular medicine · 2009Article
- Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.Human heredity · 2009Article
- Micromanaging Palate Development.Perspectives on speech science and orofacial disorders · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The finding of an association between genetic variation at the transforming growth-factor alpha (TGFA) locus and nonsyndromic isolated cleft palate (CP) represents a potentially important breakthrough in our understanding of this condition. The present study was undertaken to assess the feasibility of detecting linkage to putative CP-susceptibility loci, such as TGFA. To this end, the familial recurrence pattern for CP was evaluated to determine the most likely mode of inheritance for this condition. The study took advantage of the high ascertainment and uniform registration of CP in Denmark. In addition, the study utilized estimates of familial recurrence that were obtained by register linkage and, hence, were not subject to either recall bias or the potentially biasing influence of nonresponders. The recurrence risks for first-, second-, and third-degree relatives of 1,364 nonsyndromic CP probands were estimated to be 2.74% (72/2,628), 0.28% (3/1,068), and 0.00% (0/360), respectively. These estimates are close to published estimates based on questionnaire and interview data. The population prevalence for nonsyndromic CP was, however, found to be considerable higher than usually reported (0.058% [1,456/2,523,023]). Analyses of these and previously published data, using the method presented by Risch, indicated that major-locus or additive multilocus inheritance of CP is unlikely. The familial recurrence pattern was, however, consistent with CP being determined by several interacting loci. Under such a model, a single locus accounting for more than a sixfold increase in the risk to first-degree relatives of CP probands is unlikely, whereas a single locus accounting for a threefold increase provided a good fit to the data. Such a locus could be detected in a realistic sample of affected sib pairs.
Indexed as
Identifiers
8554055PMC1914943What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.