ArticleProceedings of the National Academy of Sciences of the United States of America1996
Cloning and expression of a gene encoding an integrin-like protein in Candida albicans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 146 citations in OpenAlex.
- The grand escape - how pathogens outsmart the human complement system.Immunobiology · 2025Review
- Exploring SARS-CoV2 host-pathogen interactions and associated fungal infections cross-talk: Screening of targets and understanding pathogenesis.Computational and structural biotechnology journal · 2022Article
- Integrins in disguise - mechanosensors inMicrobial cell (Graz, Austria) · 2019Review
- The anillin-related Int1 protein and the Sep7 septin collaborate to maintain cellular ploidy in Candida albicans.Scientific reports · 2018Article
- Thigmo Responses: The Fungal Sense of Touch.Microbiology spectrum · 2017Review
- Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms.Cellular and molecular life sciences : CMLS · 2016Review
- Effect of long-term exposure to mobile phone radiation on alpha-Int1 gene sequence of Candida albicans.Saudi journal of biological sciences · 2016Article
- A secretory protein of necrotrophic fungus Sclerotinia sclerotiorum that suppresses host resistance.PloS one · 2013Article
- Structure and function of a fungal adhesin that binds heparin and mimics thrombospondin-1 by blocking T cell activation and effector function.PLoS pathogens · 2013Article
- The role of epithelial integrin receptors in recognition of pulmonary pathogens.Journal of innate immunity · 2009Review
- Review
- Superantigen-like effects of a Candida albicans polypeptide.The Journal of infectious diseases · 2008Article
- Environmental sensing and signal transduction pathways regulating morphopathogenic determinants of Candida albicans.Microbiology and molecular biology reviews : MMBR · 2007Review
- Identification of a novel adhesion molecule involved in the virulence of Legionella pneumophila.Infection and immunity · 2005Article
- Gadolinium effects on gigaseal formation and the adhesive properties of a fungal amoeboid cell, the slime mutant of Neurospora crassa.The Journal of membrane biology · 2004Article
- EAP1, a Candida albicans gene involved in binding human epithelial cells.Eukaryotic cell · 2003Article
- An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation.The Journal of cell biology · 2003Article
- Mid2p stabilizes septin rings during cytokinesis in fission yeast.The Journal of cell biology · 2003Article
- Candida albicans expresses a focal adhesion kinase-like protein that undergoes increased tyrosine phosphorylation upon yeast cell adhesion to vitronectin and the EA.hy 926 human endothelial cell line.Infection and immunity · 2002Article
- Human immunodeficiency virus type 1 Tat binds to Candida albicans, inducing hyphae but augmenting phagocytosis in vitro.Immunology · 2001Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The existence of integrin-like proteins in Candida albicans has been postulated because monoclonal antibodies to the leukocyte integrins alpha M and alpha X bind to blastospores and germ tubes, recognize a candidal surface protein of approximately 185 kDa, and inhibit candidal adhesion to human epithelium. The gene alpha INT1 was isolated from a library of C. albicans genomic DNA by screening with a cDNA probe from the transmembrane domain of human alpha M. The predicted polypeptide (alpha Int1p) of 188 kDa contains several motifs common to alpha M and alpha X: a putative I domain, two EF-hand divalent cation-binding sites, a transmembrane domain, and a cytoplasmic tail with a single tyrosine residue. An internal RGD tripeptide is also present. Binding of anti-peptide antibodies raised to potential extracellular domains of alpha Int1p confirms surface localization in C. albicans blastopores. By Southern blotting, alpha INT1 is unique to C. albicans. Expression of alpha INT1 under control of a galactose-inducible promoter led to the production of germ tubes in haploid Saccharomyces cerevisiae and in the corresponding ste12 mutant. Germ tubes were not observed in haploid yeast transformed with vector alone, in transformants expressing a galactose-inducible gene from Chlamydomonas, or in transformants grown in the presence of glucose or raffinose. Transformants producing alpha Int1p bound an anti-alpha M monoclonal antibody and exhibited enhanced aggregation. Studies of alpha Int1p reveal novel roles for primitive integrin-like proteins in adhesion and in STE12-independent morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.