ArticleProceedings of the National Academy of Sciences of the United States of America1996
Cytoplasmic dynein is associated with slow axonal transport.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 114 citations in OpenAlex.
- Dynein and dynactin move long-range but are delivered separately to the axon tip.The Journal of cell biology · 2024Article
- Cancer and Apoptosis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Imaging Diversity in Slow Axonal Transport.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Mini-review: Microtubule sliding in neurons.Neuroscience letters · 2021Review
- Finding order in slow axonal transport.Current opinion in neurobiology · 2020Review
- Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.Scientific reports · 2017Article
- Dynein/dynactin is necessary for anterograde transport ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Local inhibition of microtubule dynamics by dynein is required for neuronal cargo distribution.Nature communications · 2017Article
- Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands.Nature communications · 2016Article
- Article
- Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.Experimental cell research · 2015Review
- Seeing the unseen: the hidden world of slow axonal transport.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Apoptosis and molecular targeting therapy in cancer.BioMed research international · 2014Review
- Fast vesicle transport is required for the slow axonal transport of synapsin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Selective vulnerability of synaptic signaling and metabolism to nitrosative stress.Antioxidants & redox signaling · 2012Review
- Hooks and comets: The story of microtubule polarity orientation in the neuron.Developmental neurobiology · 2011Review
- Mathematical modeling and parameter estimation of axonal cargo transport.Journal of computational neuroscience · 2010Article
- Myosin-dependent targeting of transmembrane proteins to neuronal dendrites.Nature neuroscience · 2009Article
- Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Rapid and intermittent cotransport of slow component-b proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal function is dependent on the transport of materials from the cell body to the synapse via anterograde axonal transport. Anterograde axonal transport consists of several components that differ in both rate and protein composition. In fast transport, membranous organelles are moved along microtubules by the motor protein kinesin. The cytoskeleton and the cytomatrix proteins move in the two components of slow transport. While the mechanisms underlying slow transport are unknown, it has been hypothesized that the movement of microtubules in slow transport is generated by sliding. To determine whether dynein, a motor protein that causes microtubule sliding in flagella, may play a role in slow axonal transport, we identified the transport rate components with which cytoplasmic dynein is associated in rat optic nerve. Nearly 80% of the anterogradely moving dynein was associated with slow transport, whereas only approximately 15% of the dynein was associated with the membranous organelles of anterograde fast axonal transport. A segmental analysis of the transport of dynein through contiguous regions of the optic nerve and tract showed that dynein is associated with the microfilaments and other proteins of slow component b. Dynein from this transport component has the capacity to bind microtubules in vitro. These results are consistent with the hypothesis that cytoplasmic dynein generates the movement of microtubules in slow axonal transport. A model is presented to illustrate how dynein attached to the slow component b complex of proteins is appropriately positioned to generate force of the correct polarity to slide microtubules down the axon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.