Evidence map›Paper›PMID 8551622›Full record

ArticleJournal of virology1996

Efficient transactivation of the minute virus of mice P38 promoter requires upstream binding of NS1.

C Lorson, L R Burger, M Mouw, D J Pintel

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  10. DNA virus replication compartments.Journal of virology · 2014
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C LorsonDepartment of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia 65212, USA.
L R Burger
M Mouw
D J Pintel
University of Missouri · US

Funding

MOLECULAR &GENETIC ANALYSIS OF MVM GENE EXPRESSIONR01AI021302 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PINTEL, DAVID J. · 1985 to 2008
$2.4M
MOLECULAR ASPECTS OF MICROBIAL PATHOGENESIST32AI007276 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI SMITH, ARNOLD LEE · 1987 to 2001
$312k
NIAID NIH HHS R01 AI21302NIAID NIH HHS T32 AI07276
6 · The paper itself

Abstract

The P38 promoter of the autonomous parvovirus minute virus of mice is strongly transactivated by the nonstructural protein NS1, a sequence-specific DNA-binding protein. In the context of the complete viral genome, the only unique cis-acting signals required for P38 transactivation by NS1 are the proximal Sp1 site and the TATA element. In the absence of additional upstream sequences, a dependence upon the NS1 binding site within the transactivation response region is observed. Addition of synthetic NS1 binding sites to transactivation response region deletion mutants can restore the ability of NS1 to transactivate P38, and NS1 transactivation has been directly correlated to its ability to bind upstream of the P38 promoter.

Indexed as

Promoter Regions, GeneticTranscriptional ActivationAmino Acid SequenceAnimalsBase SequenceBinding SitesCell LineDNA, ViralGene Expression Regulation, ViralGenome, ViralMiceMinute Virus of MiceMolecular Sequence DataProtein BindingSequence DeletionSp1 Transcription FactorDNA, ViralNS1 protein, minute virus of miceSp1 Transcription FactorViral Nonstructural Proteins

Identifiers

PMID8551622
PMCPMC189886
OpenAlexW1483512160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.