ArticleThe Journal of experimental medicine1996
HCC-1, a novel chemokine from human plasma.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- Performance of urinary C-C motif chemokine ligand 14 for the prediction of persistent acute kidney injury: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2025Article
- CCDC137 knockdown suppresses bladder cancer progression by downregulating SCD.Journal of translational medicine · 2025Article
- Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery.Intensive care medicine · 2025Article
- Chemokine ligand 14 correlates with immune cell infiltration in the gastric cancer microenvironment in predicting unfavorable prognosis.Frontiers in pharmacology · 2024Article
- Chemokine CCL14 affected the clinical outcome and correlated with immune infiltrates in thyroid carcinoma.Histology and histopathology · 2023Article
- Matrix metalloproteinase-21 promotes metastasis via increasing the recruitment and M2 polarization of macrophages in HCC.Cancer science · 2023Article
- Advances in laboratory detection of acute kidney injury.Practical laboratory medicine · 2022Article
- Conceptual advances and evolving terminology in acute kidney disease.Nature reviews. Nephrology · 2021Review
- CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of the Ligands of Receptors CCR1, CCR2, CCR3, and CCR4.International journal of molecular sciences · 2020Review
- C-C motif chemokine 14 as a novel potential biomarker for predicting the prognosis of epithelial ovarian cancer.Oncology letters · 2020Article
- CCL14 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma.Aging · 2020Article
- A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.Nature medicine · 2019Article
- An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.Cytokine · 2017Article
- Article
- The Relationship of Novel Plasma Proteins in the Early Neonatal Period With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2016Article
- Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease.JCI insight · 2016Article
- Candida albicans Induces Metabolic Reprogramming in Human NK Cells and Responds to Perforin with a Zinc Depletion Response.Frontiers in microbiology · 2016Article
- Article
- Citrullination and proteolytic processing of chemokines by Porphyromonas gingivalis.Infection and immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel CC chemokine, HCC-1, was isolated from the hemofiltrate of patients with chronic renal failure. HCC-1 has a relative molecular mass of 8,673 and consists of 74 amino acids including four cysteines linked to disulfide bonds. HCC-1 cDNA was cloned from human bone marrow and shown to code for the mature protein plus a putative 19-residue leader sequence. Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines. Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma. HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T lymphocytes, neutrophils, and eosinophil leukocytes. In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells. It was as effective as MIP-1 alpha, but about 100-fold less potent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.