ArticleThe Journal of experimental medicine1996
Regulation of T cell receptor delta gene rearrangement by c-Myb.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment.Frontiers in immunology · 2022Article
- Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.International journal of molecular sciences · 2020Review
- Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Transcription · 2015Review
- The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage.Nature immunology · 2010Article
- c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.The EMBO journal · 2007Article
- EGFR Intron Recombination in Human Gliomas: Inappropriate Diversion of V(D)J Recombination?Current genomics · 2007Article
- Genomic structure around joining segments and constant regions of swine T-cell receptor alpha/delta (TRA/TRD) locus.Immunology · 2003Article
- Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus.Immunologic research · 2000Review
- Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Review
- c-Myb is essential for early T cell development.Genes & development · 1999Article
- Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo.Molecular and cellular biology · 1998Article
- Enhancer control of local accessibility to V(D)J recombinase.Molecular and cellular biology · 1997Article
- Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.The Journal of experimental medicine · 1997Article
- Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Developmental activation of VDJ recombination at the T cell receptor (TCR) delta locus is controlled by an intronic transcriptional enhancer (E delta). Transcriptional activation by E delta is dependent on c-Myb. To determine whether c-Myb plays a role in the activation of TCR-delta gene rearrangement, we compared VDJ recombination in transgenic mice carrying two versions of a human TCR-delta gene minilocus recombination substrate. One includes a wild-type E delta, whereas the other carries an E delta with a mutation that abrogates c-Myb binding. We demonstrate that an intact Myb binding site is necessary for efficient rearrangement of the minilocus substrate, suggesting that c-Myb plays a crucial role in activating VDJ recombination at the endogenous TCR-delta locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.