ArticleThe Journal of clinical investigation1996
Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 98 citations in OpenAlex.
- Effect of meal sequence on postprandial lipid, glucose and insulin responses in young men.European journal of clinical nutrition · 2003Trial
- Readdressing the Localization of Apolipoprotein E (APOE) in Mitochondria-Associated Endoplasmic Reticulum (ER) Membranes (MAMs): An Investigation of the Hepatic Protein-Protein Interactions of APOE with the Mitochondrial Proteins Lon Protease (LONP1), Mitochondrial Import Receptor Subunit TOM40 (TOMM40) and Voltage-Dependent Anion-Selective Channel 1 (VDAC1).International journal of molecular sciences · 2024Article
- Screening program for familial hyperchylomicronemia syndrome detection: Experience of a university health system.Archives of endocrinology and metabolism · 2023Article
- Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats.Genes & nutrition · 2023Review
- Quantile-dependent expressivity of postprandial lipemia.PloS one · 2020Article
- [Apolipoprotein E polymorphism in the population of northern Morocco: frequency and effect on lipid parameters].The Pan African medical journal · 2013Article
- Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Vitamin K nutrition, metabolism, and requirements: current concepts and future research.Advances in nutrition (Bethesda, Md.) · 2012Review
- Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention.The American journal of clinical nutrition · 2009Article
- ApoE epsilon2/epsilon3/epsilon4 polymorphism, ApoC-III/ApoE ratio and metabolic syndrome.Clinical and experimental medicine · 2007Article
- Postprandial lipemia and coronary risk.Current atherosclerosis reports · 2000Review
- Apo E structure determines VLDL clearance and atherosclerosis risk in mice.The Journal of clinical investigation · 1999Article
- Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.The Journal of clinical investigation · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The postprandial responses of apo B48, B100, E and lipids in triglyceride-rich lipoproteins (TRL) to a meal containing one-third of daily energy (39% fat calories) were compared in normolipidemic young men with apo E3/3 and apo E4/3 phenotypes. After the two groups consumed a diet rich in polyunsaturated fat for 15-29 d, their postabsorptive concentrations of TRL triglycerides, apo B48, and apo B100 were virtually identical, but their postprandial responses differed. In both groups, TRL apo B48 increased at 3 h but returned to postabsorptive values at 6 h only in the apo E3/3 group; in the apo E4/3 group the concentration of apo B48 at 6 h was 80% higher than postabsorptive values. TRL apo B100 also increased at 3 h in the two groups and fell to post-absorptive values at 6 h in the apo E3/3 group but remained 51% higher than postabsorptive concentrations in the apo E4/3 group; this response was closely coupled to that of TRL cholesterol and apo E. These observations suggest that clearance of intestinal and hepatogenous TRL remnants is impaired in young men with an apo E4/3 phenotype.
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