ArticleThe Journal of clinical investigation1996
Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 140 citations in OpenAlex.
- Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.Nature aging · 2026Article
- Identification of Anoikis-Related Genes in Spinal Cord Injury: Bioinformatics and Experimental Validation.Molecular neurobiology · 2024Article
- HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures.Life science alliance · 2024Article
- Glycyrrhizin Blocks the Detrimental Effects of HMGB1 on Cortical Neurogenesis After Traumatic Neuronal Injury.Brain sciences · 2020Article
- A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation.Journal of neuroinflammation · 2020Article
- p120-catenin-dependent collective brain infiltration by glioma cell networks.Nature cell biology · 2020Article
- Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.Nature communications · 2019Article
- Morphological characterization of NG2 glia and their association with neuroglial cells in the 3-nitropropionic acid-lesioned striatum of rat.Scientific reports · 2018Article
- Fibroblast growth factors in the management of spinal cord injury.Journal of cellular and molecular medicine · 2018Review
- Astrocyte spreading and migration on aggrecan-laminin dot gradients.Biointerphases · 2017Article
- Regulation of microtubule-associated motors drives intermediate filament network polarization.The Journal of cell biology · 2017Article
- Astrocytes in Migration.Neurochemical research · 2017Review
- A novel method for culturing stellate astrocytes reveals spatially distinct Ca2+ signaling and vesicle recycling in astrocytic processes.The Journal of general physiology · 2017Article
- In vitro models of axon regeneration.Experimental neurology · 2017Review
- Serum Levels of IL-1 β , IL-6, TGF- β , and MMP-9 in Patients Undergoing Carotid Artery Stenting and Regulation of MMP-9 in a New In Vitro Model of THP-1 Cells Activated by Stenting.Mediators of inflammation · 2015Article
- Role and Importance of IGF-1 in Traumatic Brain Injuries.BioMed research international · 2015Review
- Adherens junction treadmilling during collective migration.Nature cell biology · 2014Article
- Review
- Clonal astrocytic response to cortical injury.PloS one · 2013Article
- Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The poor ability of mammalian central nervous system (CNS) axons to regenerate has been attributed, in part, to astrocyte behavior after axonal injury. This behavior is manifested by the limited ability of astrocytes to migrate and thus repopulate the injury site. Here, the migratory behavior of astrocytes in response to injury of CNS axons in vivo was simulated in vitro using a scratch-wounded astrocytic monolayer and soluble substances derived from injured rat optic nerves. The soluble substances, applied to the scratch-wounded astrocytes, blocked their migration whereas some known wound-associated factors such as transforming growth factor-beta 1 (TGF-beta 1), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and heparin-binding epidermal growth factor in combination with insulin-like growth factor-1 (HB-EGF + IGF-1) stimulated intensive migration with consequent closure of the wound. Migration was not dominated by proliferating cells. Both bFGF and HB-EGF + IGF-1, but not TGF-beta 1, could overcome the blocking effect of the optic nerve-derived substances on astrocyte migration. The induced migration appeared to involve proteoglycans. It is suggestive that appropriate choice of growth factors at the appropriate postinjury period may compensate for the endogenous deficiency in glial supportive factors and/or presence of glial inhibitory factors in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.