ArticleJournal of bacteriology1996
Role of adenine deaminase in purine salvage and nitrogen metabolism and characterization of the ade gene in Bacillus subtilis.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Pentose bisphosphate pathway can act in central metabolism for nucleoside-dependent growth ofApplied and environmental microbiology · 2025Article
- The C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination.The Biochemical journal · 2025Article
- Pan-genome-scale metabolic modeling ofmSystems · 2024Article
- The metabolic engineering of Escherichia coli for the high-yield production of hypoxanthine.Microbial cell factories · 2024Article
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- Biochemical Characterization ofFrontiers in bioengineering and biotechnology · 2018Article
- Allantoin transport protein, PucI, from Bacillus subtilis: evolutionary relationships, amplified expression, activity and specificity.Microbiology (Reading, England) · 2016Article
- Genes Associated with Desiccation and Osmotic Stress in Listeria monocytogenes as Revealed by Insertional Mutagenesis.Applied and environmental microbiology · 2015Article
- Article
- Adenine aminohydrolase from Leishmania donovani: unique enzyme in parasite purine metabolism.The Journal of biological chemistry · 2012Article
- Phylogenetic analysis and comparative genomics of purine riboswitch distribution in prokaryotes.Evolutionary bioinformatics online · 2012Article
- Efficiency of purine utilization by Helicobacter pylori: roles for adenosine deaminase and a NupC homolog.PloS one · 2012Article
- The catalase activity of diiron adenine deaminase.Protein science : a publication of the Protein Society · 2011Article
- Enzymatic deamination of the epigenetic base N-6-methyladenine.Journal of the American Chemical Society · 2011Article
- [(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions.Purinergic signalling · 2007Article
- Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle.Molecular microbiology · 2007Article
- The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi.Molecular microbiology · 2007Article
- Uptake of CdSe and CdSe/ZnS quantum dots into bacteria via purine-dependent mechanisms.Applied and environmental microbiology · 2005Article
- The purine efflux pump PbuE in Bacillus subtilis modulates expression of the PurR and G-box (XptR) regulons by adjusting the purine base pool size.Journal of bacteriology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The isolation of mutants defective in adenine metabolism in Bacillus subtilis has provided a tool that has made it possible to investigate the role of adenine deaminase in adenine metabolism in growing cells. Adenine deaminase is the only enzyme that can deaminate adenine compounds in B. subtilis, a reaction which is important for adenine utilization as a purine and also as a nitrogen source. The uptake of adenine is strictly coupled to its further metabolism. Salvaging of adenine is inhibited by the stringent response to amino acid starvation, while the deamination of adenine is not. The level of adenine deaminase was reduced when exogenous guanosine served as the purine source and when glutamine served as the nitrogen source. The enzyme level was essentially the same whether ammonia or purines served as the nitrogen source. Reduced levels were seen on poor carbon sources. The ade gene was cloned, and the nucleotide sequence and mRNA analyses revealed a single-gene operon encoding a 65-kDa protein. By transductional crosses, we have located the ade gene to 130 degrees on the chromosomal map.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.