ArticleInfection and immunity1996
Pseudomonas aeruginosa strains possess specific adhesins for laminin.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Current concepts on Pseudomonas aeruginosa interaction with human airway epithelium.PLoS pathogens · 2023Review
- Sialic Acids as Receptors for Pathogens.Biomolecules · 2021Review
- Pseudomonas aeruginosa uses multiple receptors for adherence to laminin during infection of the respiratory tract and skin wounds.Scientific reports · 2019Article
- Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age.Infection and immunity · 2018Review
- Corneal surface glycosylation is modulated by IL-1R andFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa.Pathogens and disease · 2014Review
- Type IV pilus of Pseudomonas aeruginosa confers resistance to antimicrobial activities of the pulmonary surfactant protein-A.Journal of innate immunity · 2014Article
- Avian pathogenic Escherichia coli bind fibronectin and laminin.Veterinary research communications · 2009Article
- The role of epithelial integrin receptors in recognition of pulmonary pathogens.Journal of innate immunity · 2009Review
- Identification of a Treponema pallidum laminin-binding protein.Infection and immunity · 2003Article
- Purification and partial characterization of a 32-kilodalton sialic acid-specific lectin from Aspergillus fumigatus.Infection and immunity · 2002Article
- Isolation of a laminin-binding protein from the protozoan parasite Leishmania donovani that may mediate cell adhesion.The Biochemical journal · 1999Article
- Sialic acid-dependent recognition of laminin by Penicillium marneffei conidia.Infection and immunity · 1998Article
- Filament tip-associated antigens involved in adherence to and invasion of murine pulmonary epithelial cells in vivo and HeLa cells in vitro by Nocardia asteroides.Infection and immunity · 1998Article
- Identification of the N-acetylneuraminyllactose-specific laminin-binding protein of Helicobacter pylori.Infection and immunity · 1997Article
- Expression and identification of a laminin-binding protein in Aspergillus fumigatus conidia.Infection and immunity · 1997Article
- L'inflammation dans la Mucoviscidose.Mediators of inflammation · 1996Article
- Inflammation in cystic fibrosis.Mediators of inflammation · 1996Article
- Prospects for the prevention and control of pseudomonal infection in children with cystic fibrosis.Paediatric drugsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas aeruginosa is a major human pathogen known to infect tissues that have been previously damaged in some way. In wounded human respiratory tissues, P. aeruginosa cells were found attached to exposed basement membranes following epithelial denudation, suggesting that the affinity for extracellular matrix proteins may account for the bacterium's opportunistic character. By using microtiter wells coated with different P. aeruginosa strains, we demonstrated that laminin binds to both colonizing bacterial strains, isolated from asymptomatic carriers, and strains isolated from infected patients. Binding of soluble laminin to piliated P. aeruginosa PAK and to the nonpiliated isogenic mutant PAK/p--was shown to be saturable. Binding of laminin to the piliated PAK strain was not different from binding to th nonpiliated PAK/p--strain but was significantly higher than binding to the avirulent, nonpiliated PAK-N1 rpoN mutant. By transmission electron microscopy, we localized the laminin-binding sites on a loose material in the outermost layer of the bacteria. Western immunoblotting results suggested that 57- and 59-kDa nonpilus adhesins from the microbial outer membranes account for the binding of P. aeruginosa to laminin. We speculate that bacterial affinity for laminin may be of biological significance in the pathogenesis of P. aeruginosa infection of injured tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.