ArticleGut1995
Coeliac disease and bone mineral density in adult female patients.
Article in Gut, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Guideline
- Celiac disease and bone.Archives of endocrinology and metabolism · 2022Review
- Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease.Nutrients · 2020Review
- Risk factors associated with osteoporosis in a cohort of prospectively diagnosed adult coeliac patients.United European gastroenterology journal · 2018Article
- Alendronate-induced unmasking or deterioration of coeliac disease: a case series.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach.Nutrients · 2013Review
- Evaluation and management of skeletal health in celiac disease: position statement.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Review
- Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2012Article
- Role of Alendronate in Managing Osteoporosis in Celiac Disease - Illustrative Case Report.Gastroenterology research · 2011Article
- Bone pain and extremely low bone mineral density due to severe vitamin D deficiency in celiac disease.Archives of osteoporosis · 2011Article
- Celiac disease: an underappreciated issue in women’s health.Women's health (London, England) · 2010Review
- Bone in celiac disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Review
- Long-term fracture risk in patients with celiac disease: a population-based study in Olmsted County, Minnesota.Digestive diseases and sciences · 2008Article
- Complications of coeliac disease: are all patients at risk?Postgraduate medical journal · 2006Review
- Excess non-spine fractures in women over 50 years with celiac disease: a cross-sectional, questionnaire-based study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Article
- Case-finding for adult celiac disease in patients with reduced bone mineral density.Digestive diseases and sciences · 2005Article
- Article
- Article
- The clinical impact of metabolic bone disease in coeliac disease.Postgraduate medical journal · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A cross sectional study was undertaken to examine the relationship between coeliac disease and bone mineral density. The 135 female coeliac patients registered on the database of the Department of Gastroenterology at Hull Royal Infirmary were approached by letter, advising them of a potential risk of osteoporosis and inviting them to undergo bone densitometry. A total of 81 registered women (60%) attended the Osteoporosis Laboratory, Princess Royal Hospital and underwent dual energy x ray absorptiometry at the lumbar spine (L2-L4) and femoral neck. Historical data relating to the time of diagnosis and adherence to a gluten free diet were obtained. A control group was selected from the local normal population and was first matched for height, weight, and menopausal status. Postmenopausal patients were then further matched to controls of equivalent menopausal age. In coeliac patients, bone mineral density expressed in g/cm2 as mean (SD) was significantly lower at the lumbar spine (1.076 (0.186)) than in the control group (1.155 (0.143), p < 0.001). This was also the case at the femoral neck (0.887 (0.142) versus 0.965 (0.127), p < 0.001). When the coeliac patients were stratified by menopausal status, it was found that femoral neck bone mineral density was significantly below control values in both premenopausal and postmenopausal women. Spinal bone mineral density exhibited a significant decrement only in the postmenopausal group. The age at diagnosis of coeliac disease and adherence to a gluten free diet did not influence bone mineral density at either hip or spine. These results confirm coeliac patients' higher risk of osteopenia. Coeliac disease should be added to the list of medical conditions which constitute an indication for bone densitometry in order that the individual risk of osteoporosis related fracture may be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.