ArticleClinical and diagnostic laboratory immunology1995
Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin.
Article in Clinical and diagnostic laboratory immunology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 133 citations in OpenAlex.
- Sepsis-associated acute kidney injury in mice and humans elicits heterogeneous renal microvascular microRNA responses.Scientific reports · 2025Article
- Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design.Frontiers in immunology · 2022Review
- Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model.Intensive care medicine experimental · 2021Article
- A nanotrap improves survival in severe sepsis by attenuating hyperinflammation.Nature communications · 2020Article
- Paeoniflorin and Hydroxysafflor Yellow A in Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction and Inhibit Proinflammatory Cytokine Production.Frontiers in pharmacology · 2020Article
- Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques (Animal models and experimental medicine · 2019Article
- HSP-Target of Therapeutic Agents in Sepsis Treatment.International journal of molecular sciences · 2019Review
- Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4Journal of leukocyte biology · 2018Article
- The relative resistance of children to sepsis mortality: from pathways to drug candidates.Molecular systems biology · 2018Article
- Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses.Frontiers in immunology · 2018Article
- Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture.Intensive care medicine experimental · 2016Article
- Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.Lab on a chip · 2016Article
- Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis.Science translational medicine · 2014Article
- Morphogenesis is not required for Candida albicans-Staphylococcus aureus intra-abdominal infection-mediated dissemination and lethal sepsis.Infection and immunity · 2014Article
- Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria.Journal of physiology and biochemistry · 2014Article
- Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction.PloS one · 2012Article
- Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza.Science translational medicine · 2010Article
- Mouse eosinophils possess potent antibacterial properties in vivo.Infection and immunity · 2009Article
- Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats.American journal of physiology. Heart and circulatory physiology · 2009Article
- Molecular and cellular aspects of sepsis-induced immunosuppression.Journal of molecular medicine (Berlin, Germany) · 2008Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6 and their pharmacomodulation were evaluated in a model of polymicrobial sepsis induced in mice by cecal ligation and puncture (CLP) and were compared with the effects of endotoxin (lipopolysaccharide [LPS]) treatment. LPS levels rose as early as 1 h after CLP and increased further after 2 and 21 h. TNF-alpha was detectable in serum, spleen, liver, and lungs during the first 4 h, with a peak 2 h after CLP. IL-1 beta was measurable in serum after 24 h, and levels increased significantly in spleen and liver 4 and 8 h after CLP. IL-6 levels increased significantly in serum throughout the first 16 h after CLP. These cytokines were detectable after LPS injection, with kinetics similar to those after CLP but at a significantly higher level. To cast more light on the differences between these two animal models of septic shock, we studied the effects of different reference drugs. Pretreatment with dexamethasone (DEX); ibuprofen (IBU), an inhibitor of cyclooxygenase; and NG-nitro-L-arginine, an inhibitor of nitric oxide synthase, significantly reduced survival, while chlorpromazine (CPZ) and TNF did not affect it. Only the antibiotics and pentoxifylline significantly increased survival in mice with CLP. However, CPZ and DEX protected the mice from LPS mortality. On inhibiting TNF-alpha with DEX, CPZ, or pentoxifylline, survival was reduced, unchanged, and increased, respectively, and on increasing TNF-alpha with IBU and TNF, survival was decreased or unchanged, respectively, suggesting that the modulation of this cytokine does not play a significant role in sepsis induced by CLP, unlike treatment with LPS. The negative effects of IBU and N(G)-nitro-L-arginine suggest a protective role by prostaglandins and nitric oxide in sepsis induced by CLP.
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