ArticleThe Biochemical journal1996
Purification and characterization of prostaglandin-H E-isomerase, a sigma-class glutathione S-transferase, from Ascaridia galli.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control.Tropical medicine and infectious disease · 2024Review
- Roles of three putative salmon louse (Lepeophtheirus salmonis) prostaglandin EParasites & vectors · 2021Article
- Allergological Importance of Invertebrate Glutathione Transferases in Tropical Environments.Frontiers in allergy · 2021Review
- Characterization of a novel glycosylated glutathione transferase ofParasitology · 2019Article
- The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.PLoS neglected tropical diseases · 2012Article
- Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.Clinical microbiology reviews · 2003Review
- A dominant role for extracellular glutathione S-transferase from Onchocerca volvulus is the production of prostaglandin D2.Infection and immunity · 2003Article
- Ultrastructural localization of 28 kDa glutathione S-transferase in adult Clonorchis sinensis.The Korean journal of parasitology · 2002Article
- Structural analysis and antibody response to the extracellular glutathione S-transferases from Onchocerca volvulus.Infection and immunity · 2001Article
- Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.The Biochemical journal · 2001Review
- Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases.The Biochemical journal · 2001Article
- Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei.The Journal of experimental medicine · 2000Article
- Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase.The Biochemical journal · 1998Article
- Structural and functional analysis of a glutathione S-transferase from Ascaris suum.The Biochemical journal · 1997Article
- Glutathione S-transferases from the white-rot fungus, Phanerochaete chrysosporium.The Biochemical journal · 1997Article
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5 authors.
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Abstract
Comparison of partial primary sequences of sigma-class glutathione S-transferases (GSH) of parasitic helminths and a GSH-dependent prostaglandin (PG)-H D-isomerase of rat immune accessory cells suggested that some of the helminth enzymes may also be involved in PG biosynthesis [Meyer and Thomas (1995) Biochem. J. 311, 739-742]. A soluble GSH transferase of the parasitic nematode Ascaridia galli has now been purified which shows high activity and specificity in the GSH-dependent isomerization of PGH to PGE, comparable to that of the rat spleen enzyme in its isomerization of PGH to PGD, and similarly stimulates the activity of prostaglandin H synthase. The enzyme subunit is structurally related to the rat spleen enzyme and sigma-class GSH transferases of helminths according to the partial primary sequence. The data support the hypothesis that some sigma-class GSH transferases of helminth parasites are involved in PG biosynthesis which, in the case of PGE, is likely to be associated with the subversion or suppression of host immunity. A PG-H E-isomerase of comparable specificity and activity has not previously been isolated.
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