ArticleAnnals of the rheumatic diseases1995
Factors associated with Pneumocystis carinii pneumonia in Wegener's granulomatosis.
Article in Annals of the rheumatic diseases, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- [Diagnosis and therapy of granulomatosis with polyangiitis and microscopic polyangiitis-2023: consensus of the Austrian society of nephrology (ÖGN) and Austrian society of rheumatology (ÖGR)].Wiener klinische Wochenschrift · 2023Article
- Duration of prednisone treatment before development ofJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2022Article
- Causes of acute respiratory failure in patients with small-vessel vasculitis admitted to intensive care units: a multicenter retrospective study.Annals of intensive care · 2021Article
- Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review.Yonsei medical journal · 2019Review
- Birmingham vasculitis activity and chest manifestation at diagnosis can predict hospitalised infection in ANCA-associated vasculitis.Clinical rheumatology · 2018Article
- Late-onset Pneumocystis jirovecii pneumonia (PJP) in patients with ANCA-associated vasculitis.Clinical rheumatology · 2018Article
- Pneumocystis Pneumonia and the Rheumatologist: Which Patients Are At Risk and How Can PCP Be Prevented?Current rheumatology reports · 2017Review
- Cytomegalovirus Pneumonia in Patients with Rheumatic Diseases After Immunosuppressive Therapy: A Single Center Study in China.Chinese medical journal · 2016Article
- Infection Risk and Safety of Corticosteroid Use.Rheumatic diseases clinics of North America · 2016Review
- A case of granulomatosis with polyangiitis complicated by cyclophosphamide toxicity and opportunistic infections: choosing between Scylla and Charybdis.BMC nephrology · 2014Article
- [Lymphocytopenia: aetiology and diagnosis, when to think about idiopathic CD4(+) lymphocytopenia?].La Revue de medecine interne · 2012Article
- 69-year-old woman with dyspnea and cough productive of white sputum.Mayo Clinic proceedings · 2011Article
- Conditions in subjects with rheumatic diseases: pulmonary manifestations of vasculitides.Arthritis research & therapy · 2011Review
- Pneumocystis jiroveci pneumonia in giant cell arteritis: A case series.Arthritis care & research · 2011Article
- Update on the diagnosis and treatment of Pneumocystis pneumonia.Therapeutic advances in respiratory disease · 2011Review
- Wegener's granulomatosis: experience from a Brazilian tertiary center.Clinical rheumatology · 2010Article
- Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?Arthritis research & therapy · 2009Review
- [Diagnosis of lymphocytopenia].Presse medicale (Paris, France : 1983) · 2006Review
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the factors associated with the occurrence of Pneumocystis carinii pneumonia (PCP) in Wegener's granulomatosis (WG).
methodsWe retrospectively compared a group of 12 patients with WG and PCP (PCP group), with 32 WG patients without PCP followed over the same period in the same centres (control group).
resultsThe mean delay of onset of PCP after the start of the immunosuppressive therapy was 127 (SD 128) days. Before treatment, the clinical and biological features of the two groups were similar, except for the mean lymphocyte count which was lower in the PCP group than in the control group (1060/mm3 v 1426/mm3; p = 0.04). During treatment, both groups were lymphopenic. There was a significant difference between the lowest absolute lymphocyte count in each group (244/mm3 in the PCP group v 738/mm3 in the control group; p = 0.001). During the first three months of treatment, the lymphocyte count was less than 600/mm3 at least once in 10 of the 12 patients in the PCP group and in 11 of the 32 patients in the control group (p < 0.01). The mean cumulative dose of cyclophosphamide was greater in the PCP group than in the control group at the end of both the second (1.55 mg/kg/day v 0.99 mg/kg/day; p = 0.05) and the third (1.67 mg/kg/day v 0.97 mg/kg/day; p = 0.03) months. However, in multivariate analysis, the only two factors independently and significantly associated with the occurrence of PCP were the pretreatment lymphocyte count (p = 0.018) and the lymphocyte count three months after the start of the immunosuppressive treatment (p = 0.014).
conclusionsThe severity of lymphocytopenia before and during immunosuppressive treatment is the factor best associated with PCP in WG.
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