ArticleThe American journal of pathology1996
Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 45 citations in OpenAlex.
- Heavy Metal Ions Removal from Aqueous Solutions by Treated Ajwa Date Pits: Kinetic, Isotherm, and Thermodynamic Approach.Polymers · 2022Article
- Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice.Aging cell · 2020Article
- S-allyl Cysteine, a Garlic Compound, Produces an Antidepressant-Like Effect and Exhibits Antioxidant Properties in Mice.Brain sciences · 2020Article
- Cell type-specific expression analysis to identify putative cellular mechanisms for neurogenetic disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Antioxidant Effects of Spinach (Spinacia oleracea L.) Supplementation in Hyperlipidemic Rats.Preventive nutrition and food science · 2014Article
- A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2009Review
- Nitrite/nitrate (NOx) and zinc concentrations in influenza-associated encephalopathy in children with different sequela.Neurochemical research · 2005Article
- Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions.The American journal of pathology · 1999Article
- Oxidative stress and motor neurone disease.Brain pathology (Zurich, Switzerland) · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has been implicated in the pathogenesis of several neurological disorders. We examined the regional distribution of copper/zinc superoxide dismutase (SOD-1), one of the key antioxidant enzymes, in the human central nervous system using in situ hybridization. Our results show that the enzyme is present at high levels of constitutive expression in alpha-motor neurons, oculomotor neurons, nucleus basalis, substantia nigra, neocortex, and the hippocampal sector resistant to hypoxia (H2). Relatively lower levels were found in Sommer's sector (H1) and Purkinje cells. We conclude that a lower constitutive level of SOD-1 expression may play a role in the selective vulnerability of certain neuronal populations to hypoxia but does not correlate with the patterns of neurodegeneration observed in amyotrophic lateral sclerosis. Parkinson's disease, and Alzheimer's disease.
Indexed as
Identifiers
8546216PMC1861609W279197445What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.