ArticleMolecular & general genetics : MGG1995
Inactivation of the yeast Sen1 protein affects the localization of nucleolar proteins.
Article in Molecular & general genetics : MGG, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease.Molecular genetics & genomic medicine · 2021Review
- Article
- Cell-Cycle Modulation of Transcription Termination Factor Sen1.Molecular cell · 2018Article
- Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.Genetics · 2014Article
- Article
- Interactions of Sen1, Nrd1, and Nab3 with multiple phosphorylated forms of the Rpb1 C-terminal domain in Saccharomyces cerevisiae.Eukaryotic cell · 2012Article
- Yeast Sen1 helicase protects the genome from transcription-associated instability.Molecular cell · 2011Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
- MAA3 (MAGATAMA3) helicase gene is required for female gametophyte development and pollen tube guidance in Arabidopsis thaliana.Plant & cell physiology · 2008Article
- Shuffling of promoters for multiple genes to optimize xylose fermentation in an engineered Saccharomyces cerevisiae strain.Applied and environmental microbiology · 2007Article
- In cis autosomal dominant mutation of Senataxin associated with tremor/ataxia syndrome.Neurogenetics · 2007Article
- The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins.Molecular biology of the cell · 2006Article
- Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription-coupled DNA repair and RNA processing.Nucleic acids research · 2004Article
- A well-connected and conserved nucleoplasmic helicase is required for production of box C/D and H/ACA snoRNAs and localization of snoRNP proteins.Molecular and cellular biology · 2001Article
- Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3.Molecular and cellular biology · 2000Article
- Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae.Molecular and cellular biology · 1999Review
- Transcriptional control of ADH genes in the xylose-fermenting yeast Pichia stipitis.Applied and environmental microbiology · 1999Article
- The putative nucleic acid helicase Sen1p is required for formation and stability of termini and for maximal rates of synthesis and levels of accumulation of small nucleolar RNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 1998Article
- The yeast SEN1 gene is required for the processing of diverse RNA classes.Nucleic acids research · 1997Article
- Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
A mutation in the Saccharomyces cerevisiae SEN1 gene causes accumulation of end-matured, intron-containing pre-tRNAs. Cells containing the thermosensitive sen1-1 mutation exhibit reduced tRNA splicing endonuclease activity. However, Sen1p is not the catalytic subunit of this enzyme. We have used Sen1p-specific antibodies for cell fractionation studies and immunofluorescent microscopy and determined that Sen1p is a low abundance protein of about 239 kDa. It localizes to the nucleus with a granular distribution. We verified that a region in SEN1 containing a putative nuclear localization signal sequence (NLS) is necessary for nuclear targeting. Furthermore, we found that inactivation of Sen1p by temperature shift of a strain carrying sen1-1 leads to mislocalization of two nucleolar proteins, Nop1 and Ssb1. Possible mechanisms are discussed for several related nuclear functions of Sen1p, including tRNA splicing and the maintenance of a normal crescent-shaped nucleolus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.