ArticleThe Journal of physiology1995
5-HT2 receptor-controlled modulation of medullary respiratory neurones in the cat.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 58 citations in OpenAlex.
- Interactions between lorcaserin and opioids: Ventilation and food-versus-drug choice.Pharmacology, biochemistry, and behavior · 2024Article
- Quipazine Elicits Swallowing in the Arterially Perfused Rat Preparation: A Role for Medullary Raphe Nuclei?International journal of molecular sciences · 2020Article
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive Physiology · 2019Review
- Breathing: Motor Control of Diaphragm Muscle.Physiology (Bethesda, Md.) · 2018Review
- Central and peripheral factors contributing to obstructive sleep apneas.Respiratory physiology & neurobiology · 2013Review
- Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.PloS one · 2011Article
- The role of serotonin in respiratory function and dysfunction.Respiratory physiology & neurobiology · 2010Review
- Pathophysiology of sleep apnea.Physiological reviews · 2010Review
- Bioaminergic neuromodulation of respiratory rhythm in vitro.Respiratory physiology & neurobiology · 2009Review
- Medullary serotonin defects and respiratory dysfunction in sudden infant death syndrome.Respiratory physiology & neurobiology · 2009Review
- Medullary serotonin neurons and central CO2 chemoreception.Respiratory physiology & neurobiology · 2009Review
- Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat.Brain research · 2009Article
- Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects.Respiratory physiology & neurobiology · 2008Review
- Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Protein kinase C pathways modulate respiratory pattern generation in the cat.The Journal of physiology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. The effects of the 5-HT2 receptor agonist alpha-methyl-5-HT were studied on the membrane of expiratory (E2) and post-inspiratory (PI) neurones, by intracellular recordings in the caudal medulla of anaesthetized cats. 2. Ionophoresis of alpha-Me-5-HT depolarized membrane potential and increased action potential frequency in a majority of neurones tested. Depolarization of neurones by alpha-Me-5-HT was accompanied by increased input resistance throughout all phases of the respiratory cycle. These effects were antagonized by ionophoresis of cinanserin, a receptor-blocking agent with high affinity for 5-HT2 receptors. 3. E2 neurones were voltage clamped to measure membrane current changes induced by alpha-Me-5-HT ionophoresis. alpha-Me-5-HT induced a net inward current by reducing inspiratory-phase outward currents and increasing expiratory-phase inward currents. These changes were equivalent with steady membrane depolarization, decreased inspiratory phase membrane hyperpolarization and increased expiratory drive potential recorded from the same neurones in current clamp. 4. The effects of alpha-Me-5-HT are consistent with activation of 5-HT2 receptors on E2 and PI neurones leading to blockade of synaptically activated and persistent conductances to potassium ions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.